Oticlor 125 mg/1.25 ml (Pediatric Drops)

Title

• Oticlor

Categories

• Medicine
• Antibiotics
• Cephalosporins

Description

• Oticlor is indicated in the treatment of respiratory tract infections, otitis media, pharyngitis, tonsillitis, urinary tract infections, skin and skin structure infections.
• Cefaclor is a second generation cephalosporin antibiotic with stability against beta-lactamase inactivation and possesses a broad spectrum of activity.

DosageAndAdministration

• Capsule: Adult dose: The usual dose is 250 mg every 8 hours. For severe infections, doses may be doubled with a maximum dosage of 4 g/day.
• Powder for suspension & Pediatric drops: Children: The usual daily dosage for pediatric patients over 1 month is 20 mg/kg/day in divided doses every 8 hours. For serious infections, 40 mg/kg/day is recommended, with a maximum dosage of 1 g/day.

Indications

• Respiratory tract infections
• Otitis media
• Pharyngitis
• Tonsillitis
• Urinary tract infections
• Skin and skin structure infections

Pharmacology

• Active against Alpha and beta haemolytic Streptococci
• Active against Staphylococci, including coagulase-positive, coagulase negative, and penicillinase-producing strains
• Effective in the eradication of Streptococci from the nasopharynx

Interactions

• May show a false-positive reaction for glucose in the urine with tests that use Benedict's solution, Fehling's solutions
• Reports of increased anticoagulant effect when administered concomitantly with oral anticoagulants

Contraindications

• Contraindicated in patients with known allergy to the Cephalosporin group of antibiotics

SideEffects

• Gastro-intestinal symptoms may occur including diarrhea, nausea, vomiting
• Transient hepatitis and cholestatic jaundice reported rarely
• Fever, abdominal pain, superinfection, renal dysfunction, toxic nephropathy, hemorrhage, elevated LDH, pancytopenia may occur

PregnancyAndLactation

• No adequate and well-controlled studies in pregnant women
• Small amounts detected in mother's milk
• Caution should be exercised when administered to a nursing woman

PrecautionsAndWarnings

• Prescribing in the absence of a proven or strongly suspected bacterial infection or a prophylactic indication is unlikely to provide benefit to the patient
• Prolonged use may result in the overgrowth of nonsusceptible organisms
• Renal excretion is inhibited by Probenecid

OverdoseEffects

• Toxic symptoms may include nausea, vomiting, epigastric distress, and diarrhea

TherapeuticClass

• Second generation Cephalosporins

Reconstitution

• Powder for Suspension: Shake the bottle well before mixing the water. To prepare 100 ml suspension, add 62.5 ml of boiled & cooled water in two portions and shake till powder is completely mixed with water.

StorageConditions

• Store at room temperature and protect from light. After reconstitution, the suspension can be used within 7 days if kept at room temperature and within 14 days if kept in a refrigerator.

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