Cefstar 500 mg (Tablet)

Unit Price: ৳ 45.16 (8's pack: ৳ 361.28)

Medicine Details

Category	Details
Generic	Cefuroxime axetil
Company	Pharmadesh laboratories ltd
Also available as	Cefstar 125 mg tablet Cefstar 250 mg tablet Cefstar 125 mg suspension

Indications

Pharyngitis/Tonsillitis caused by Streptococcus pyogenes
Acute Bacterial Otitis Media caused by Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis
Acute bacterial maxillary sinusitis caused by Streptococcus pneumoniae or Haemophilus influenzae
Lower respiratory tract infections including pneumoniae, caused by various bacteria
Skin and skin-structure infections caused by Staphylococcus aureus or Streptococcus pyogenes
Urinary tract infections caused by E.coli or Klebsiella pneumoniae
Bone and Joint Infections caused by Staphylococcus aureus
Gonorrhoea caused by penicillinase-producing and non-penicillinase producing strains of Neisseria gonorrhoeae
Early Lyme Disease (erythema migrans) caused by Borrelia burgdorferi

Pharmacology

Cefuroxime is a well-characterized and effective antibacterial agent with broad-spectrum bactericidal activity against a wide range of common pathogens, including beta-lactamase producing strains.

Dosage

Tablet or Suspension:
- Adolescents and Adults (13 years and older):
  - 250 mg b.i.d. for various durations based on infection type
- Paediatric Patients (3 months to 12 years):
  - Doses based on body weight and specific infection type
Parenteral:
- Adult:
  - 750 mg-1.5 gm three times daily by IM or IV injection, frequency may be increased if necessary
  - Surgical prophylaxis dosing
  - Pneumonia doses
  - Acute exacerbations of chronic bronchitis doses
  - Gonorrhoea dose
  - Meningitis dose
  - Bone and joint infections dose
- Children (above 3 months of age):
  - Dosing based on body weight and specific infection type
- Neonate:
  - Dosing based on body weight and specific infection type

Administration

The use of freshly reconstituted solution is recommended. It maintains potency for at least 24 hours at room temperature or 48 hours at 5°C.

Interaction

No potentially hazardous interactions reported.

Contraindications

Cefuroxime is contraindicated in patients with known allergy to Cephalosporins.

Side Effects

Adverse effects to Cefuroxime have occurred infrequently and have been generally mild and transient in nature. Effects reported include rashes and gastrointestinal disturbances. Prolonged use may result in the overgrowth of non-susceptible organisms e.g. Candida.

Pregnancy & Lactation

US FDA pregnancy category of Cefuroxime is B. Caution should be exercised when administered to a nursing woman.

Precautions & Warnings

Cefuroxime should be given with care to patients receiving concurrent treatment with potent diuretics & who has a history of colitis. Cross reactions have been reported in patients hypersensitive to penicillin although they are not likely at the recommended dose levels.

Therapeutic Class

Second generation Cephalosporins

Reconstitution

Instructions for reconstituting intramuscular and intravenous injections.

Storage Conditions

Store in a cool, dry place (below 30°C), away from light & moisture. Keep out of the reach of children.