Kilbac 125 mg (Tablet)
Medicine Details
| Category | Details |
|---|---|
| Generic | Cefuroxime axetil |
| Company | Incepta pharmaceuticals ltd |
| Also available as |
Indications
- Treatment of infections caused by sensitive bacteria
- Pharyngitis/Tonsillitis caused by Streptococcus pyogenes
- Acute Bacterial Otitis Media caused by various bacteria
- Lower respiratory tract infections including pneumoniae
- Skin and skin-structure infections
- Urinary tract infections
- Bone and Joint Infections
- Gonorrhoea caused by various strains
- Early Lyme Disease (erythema migrans) caused by Borrelia burgdorferi
Pharmacology
Cefuroxime is a well-characterized and effective antibacterial agent with broad-spectrum bactericidal activity against a wide range of common pathogens, including β-lactamase producing strains.
Dosage
- Tablet or Suspension:
- Adolescents and adults (13 years and older):
- 250 mg b.i.d. for various conditions
- Paediatric Patients (3 months to 12 years):
- 20-30 mg/kg/day b.i.d. for various conditions
- Adolescents and adults (13 years and older):
- Parenteral:
- Adult:
- 750 mg-1.5 gm three times daily by IM or IV injection
- In severe infections, dose can be increased upto 1.5 gm three times daily by IV injection
- Children (above 3 months of age):
- 30 - 100 mg/kg/day given in 3 or 4 equally divided doses
- Dose of 60 mg/kg/day is appropriate for most infections
- Neonate:
- 30 - 100 mg/kg/day given in 2 or 3 equally divided doses
- Adult:
Administration
The use of freshly reconstituted solution is recommended. It maintains potency for at least 24 hours at room temperature or 48 hours at 5°C.
Interaction
No potentially hazardous interactions reported.
Contraindications
Cefuroxime is contraindicated in patients with known allergy to Cephalosporins.
Side Effects
- Adverse effects have been generally mild and transient
- Effects reported include rashes and gastrointestinal disturbances
- Prolonged use may result in the overgrowth of non susceptible organisms e.g. Candida.
Pregnancy & Lactation
US FDA pregnancy category of Cefuroxime is B. Caution should be exercised when Cefuroxime is administered to a nursing woman.
Precautions & Warnings
- Given with care to patients receiving concurrent treatment with potent diuretics & who has history of colitis
- Cross reactions with penicillin have been reported
- Likely safe for patients hypersensitive to penicillin
- Cefuroxime available in human milk
Therapeutic Class
Second generation Cephalosporins
Reconstitution
Instructions for reconstitution for intramuscular and intravenous injections.
Storage Conditions
Store in a cool, dry place (below 30°C), away from light & moisture. Keep out of the reach of children.