Kilbac 250 mg/vial (IM/IV Injection)

250 mg vial: ৳ 55.00

Medicine Details

Category Details
Generic Cefuroxime axetil
Company Incepta pharmaceuticals ltd
Also available as
Kilbac 125 mg tablet Kilbac 250 mg tablet Kilbac 500 mg tablet Kilbac 125 mg suspension Kilbac ds 250 mg suspension Kilbac 750 mg injection Kilbac 15 gm injection

Indications

  • Pharyngitis/Tonsillitis caused by Streptococcus pyogenes
  • Acute Bacterial Otitis Media caused by Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis
  • Acute bacterial maxillary sinusitis caused by Streptococcus pneumoniae or Haemophilus influenzae
  • Lower respiratory tract infections including pneumonia caused by Streptococcus pneumoniae, Haemophilus influenzae, Klebsiella spp., Staphylococcus aureus
  • Skin and skin-structure infections caused by Staphylococcus aureus or Streptococcus pyogenes
  • Urinary tract infections caused by E.coli or Klebsiella pneumoniae
  • Bone and Joint Infections caused by Staphylococcus aureus
  • Gonorrhoea caused by penicillinase-producing and non-penicillinase producing strains of Neisseria gonorrhoeae
  • Early Lyme Disease (erythema migrans) caused by Borrelia burgdorferi

Pharmacology

Broad-spectrum bactericidal activity against a wide range of common pathogens, including β-lactamase producing strains, good stability to bacterial β-lactamase, active against many ampicillin-resistant and amoxycillin-resistant strains

Dosage

  • Tablet or Suspension:
    • Adolescents and adults (13 years and older):
      • Pharyngitis/tonsillitis: 250 mg b.i.d. for 5-10 days
      • Acute bacterial maxillary sinusitis: 250 mg b.i.d. for 10 days
      • Acute bacterial exacerbation of chronic bronchitis: 250-500 mg b.i.d. for 10 days
      • Secondary bacterial infections of acute bronchitis: 250-500 mg b.i.d. for 5-10 days
      • Uncomplicated skin and skin structure infections: 250-500 mg b.i.d. for 10 days
      • Uncomplicated urinary tract infections: 250 mg b.i.d. for 7-10 days
      • Uncomplicated Gonorrhoea: 1000 mg Single dose
      • Community acquired pneumonia: 250-500 mg b.i.d. for 5-10 days
      • MDR Typhoid Fever: 500 mg b.i.d. for 10-14 days
      • Early Lyme disease: 500 mg b.i.d. for 20 days
    • Paediatric Patients (3 months to 12 years):
      • Pharyngitis/Tonsillitis: 20 mg/kg/day b.i.d for 5-10 days
      • Acute otitis media: 30 mg/kg/day b.i.d for 10 days
      • Acute bacterial maxillary sinusitis: 30 mg/kg/day b.i.d for 10 days
      • Impetigo: 30 mg/kg/day b.i.d for 10 days
  • Parenteral:
    • Adult: 750 mg three times daily by IM or IV injection. In severe infections, dose can be increased upto 1.5 gm three times daily by IV injection
    • Children (above 3 months of age): 30 - 100 mg/kg/day given in 3 or 4 equally divided doses
    • Neonate: 30 - 100 mg/kg/day given in 2 or 3 equally divided doses
    • Surgical prophylaxis: 1.5 gm by IV injection at induction of anaesthesia; up to 3 further doses of 750 mg may be given by IV/IM injection every 8 hours for high risk procedures
    • Pneumonia: 1.5 gm IV injection twice daily for 2-3 days, followed by 500 mg twice daily (oral) for 7-10 days
    • Acute exacerbations of chronic bronchitis: 750 mg twice daily (IM or IV injection) for 2-3 days, followed by 500 mg twice daily (oral) for 5-10 days
    • Gonorrhoea: 1.5 gm as a single dose (as 2 x 750mg injections intramuscularly with different sites, e.g. each buttock)
    • Meningitis:
      • Adult: 3 gm IV injection three times daily
      • Children (above 3 months of age): 200-240 mg/kg/day by IV injection in 3 or 4 divided doses reduced to 100 mg/kg/day after 3 days or on clinical improvement
      • Neonate: 100 mg/kg/day by IV injection at initial dose, reduced to 50 mg/kg/day, When clinically indicated
    • Bone and joint infections:
      • Adult: 1.5 gm IV injection four times daily
      • Children (above 3 months of age): 150 mg/kg/day (not to exceed the maximum adult dose) in equally divided doses every 8 hours

Administration

The use of freshly reconstituted solution is recommended. Maintains potency for at least 24 hours at room temperature or 48 hours at 5<sup>o</sup> C

Interaction

No potentially hazardous interactions reported

Contraindications

Cefuroxime is contraindicated in patients with known allergy to Cephalosporins

Side Effects

  • Rashes
  • Gastrointestinal disturbances
  • Prolonged use may result in the overgrowth of non susceptible organisms e.g. Candida

Pregnancy & Lactation

US FDA pregnancy category B, caution should be exercised when Cefuroxime is administered to a nursing woman

Precautions & Warnings

Use with care in patients receiving concurrent treatment with potent diuretics &amp; who has history of colitis. Cephalosporin antibiotics may in general be given safely to patients who are hypersensitive to penicillin although cross reactions have reported.

Therapeutic Class

Second generation Cephalosporins

Reconstitution

  • For 750 mg intramuscular injection: Add 3 ml water for injection to vial and then shake gently for dispersion
  • For 750 mg intravenous injection: Add 8 ml water for injection to vial and then shake gently for dispersion. The solution should be slowly injected directly into a vein over a 3 to 5 minutes period
  • For 1.5 g intravenous injection: Add 16 ml Water for injection to vial and then shake gently for dispersion. The solution should be slowly injected directly into a vein over a 3 to 5 minutes period

Storage Conditions

Store in a cool, dry place (below 30<sup>o</sup> C), away from light &amp; moisture. Keep out of the reach of children

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