Sefurox 1.5 gm/vial (IV Injection)

1.5 gm vial: ৳ 200.60

Medicine Details

Category Details
Generic Cefuroxime axetil
Company Synovia pharma plc
Also available as
Sefurox 250 mg tablet Sefurox 500 mg tablet Sefurox 125 mg suspension Sefurox 750 mg injection

Indications

  • Treatment of infections caused by sensitive bacteria
  • Pharyngitis/Tonsillitis caused by Streptococcus pyogenes
  • Acute Bacterial Otitis Media caused by Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis
  • Acute bacterial maxillary sinusitis caused by Streptococcus pneumoniae or Haemophilus influenzae
  • Lower respiratory tract infections including pneumoniae
  • Acute bacterial exacerbation of chronic bronchitis
  • Skin and skin-structure infections
  • Urinary tract infections
  • Bone and Joint Infections
  • Gonorrhoea
  • Early Lyme Disease

Pharmacology

Cefuroxime is a well-characterized and effective antibacterial agent, which has broad-spectrum bactericidal activity against a wide range of common pathogens

Dosage

  • Tablet or Suspension:
    • Adolescents and adults (13 years and older):
      • Pharyngitis/tonsillitis: 250 mg b.i.d. for 5-10 days
      • Acute bacterial maxillary sinusitis: 250 mg b.i.d. for 10 days
      • Acute bacterial exacerbation of chronic bronchitis: 250-500 mg b.i.d. for 10 days
      • Secondary bacterial infections of acute bronchitis: 250-500 mg b.i.d. for 5-10 days
      • Uncomplicated skin and skin structure infections: 250-500 mg b.i.d. for 10 days
      • Uncomplicated urinary tract infections: 250 mg b.i.d. for 7-10 days
      • Uncomplicated Gonorrhoea: 1000 mg Single dose
      • Community acquired pneumonia: 250-500 mg b.i.d. for 5-10 days
      • MDR Typhoid Fever: 500 mg b.i.d. for 10-14 days
      • Early Lyme disease: 500 mg b.i.d. for 20 days
    • Paediatric Patients (3 months to 12 years):
      • Pharyngitis/Tonsillitis: 20 mg/kg/day b.i.d for 5-10 days
      • Acute otitis media: 30 mg/kg/day b.i.d for 10 days
      • Acute bacterial maxillary sinusitis: 30 mg/kg/day b.i.d for 10 days
      • Impetigo: 30 mg/kg/day b.i.d for 10 days
  • Parenteral:
    • Adult: 750 mg three times daily by IM or IV injection
    • Children (above 3 months of age): 30 - 100 mg/kg/day given in 3 or 4 equally divided doses
  • Meningitis:
    • Adult: 3 gm IV injection three times daily
    • Children (above 3 months of age): 200-240 mg/kg/day by IV injection in 3 or 4 divided doses reduced to 100 mg/kg/day after 3 days or on clinical improvement

Administration

The use of freshly reconstituted solution is recommended. It maintains potency for at least 24 hours at room temperature or 48 hours at 5°C

Interaction

No potentially hazardous interactions reported

Contraindications

Cefuroxime is contraindicated in patients with known allergy to Cephalosporins

Side Effects

Adverse effects have occurred infrequently and have been generally mild and transient in nature. Effects reported include rashes and gastrointestinal disturbances

Pregnancy & Lactation

  • US FDA pregnancy category of Cefuroxime is B
  • Cefuroxime have been shown to be excreted in human milk. Caution should be exercised when Cefuroxime is administered to a nursing woman

Precautions & Warnings

Sefurox should be given with care to patients receiving concurrent treatment with potent diuretics & who has history of colitis

Therapeutic Class

Second generation Cephalosporins

Reconstitution

For 750 mg intramuscular injection: Add 3 ml water for injection to vial and then shake gently for dispersion. For 750 mg intravenous injection: Add 8 ml water for injection to vial and then shake gently for dispersion. For 1.5 g intravenous injection: Add 16 ml Water for injection to vial and then shake gently for dispersion. The solution should be slowly injected directly into a vein over a 3 to 5 minutes period

Storage Conditions

Store in a cool, dry place (below 30°C), away from light & moisture. Keep out of the reach of children

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