Til 250 mg (Tablet)
Medicine Details
| Category | Details |
|---|---|
| Generic | Cefuroxime axetil |
| Company | Apex pharmaceuticals ltd |
| Also available as |
Indications
- Pharyngitis/Tonsillitis caused by Streptococcus pyogenes
- Acute Bacterial Otitis Media caused by Streptococcus pneumoniae, Haemophilus influenzae
- Acute bacterial maxillary sinusitis caused by Streptococcus pneumoniae or Haemophilus influenzae
- Lower respiratory tract infections including pneumoniae caused by Streptococcus pneumoniae, Haemophilus influenzae
- Acute bacterial exacerbation of chronic bronchitis and Secondary bacterial infections of Acute bronchitis caused by Streptococcus pneumoniae, Haemophilus influenzae
- Skin and skin-structure infections caused by Staphylococcus aureus or Streptococcus pyogenes
- Urinary tract infections caused by E.coli or Klebsiella pneumoniae
- Gonorrhoea caused by penicillinase-producing and non-penicillinase producing strains of Neisseria gonorrhoeae
- Early Lyme Disease (erythema migrans) caused by Borrelia burgdorferi
Pharmacology
Cefuroxime is a well-characterized and effective antibacterial agent with broad-spectrum bactericidal activity against a wide range of common pathogens, including β-lactamase producing strains
Dosage
- Tablet or Suspension:
- 250 mg b.i.d. for Pharyngitis/Tonsillitis
- 250 mg b.i.d. for Acute bacterial maxillary sinusitis
- 250-500 mg b.i.d. for Acute bacterial exacerbation of chronic bronchitis
- 250-500 mg b.i.d. for Secondary bacterial infections of Acute bronchitis
- 250-500 mg b.i.d. for Uncomplicated skin and skin structure infections
- 250 mg b.i.d. for Uncomplicated urinary tract infections
- 1000 mg Single dose for Uncomplicated Gonorrhoea
- Parenteral:
- Adult: 750 mg three times daily by IM or IV injection
- Children (above 3 months of age): 30 - 100 mg/kg/day given in 3 or 4 equally divided doses
- Neonate: 30 - 100 mg/kg/day given in 2 or 3 equally divided doses
- Surgical prophylaxis: 1.5 gm by IV injection at induction of anaesthesia
Administration
The use of freshly reconstituted solution is recommended. It maintains potency for at least 24 hours at room temperature or 48 hours at 5°C
Interaction
No potentially hazardous interactions reported
Contraindications
Cefuroxime is contraindicated in patients with known allergy to Cephalosporins
Side Effects
- Adverse effects to Cefuroxime have been generally mild and transient
- Rashes and gastrointestinal disturbances
- Prolonged use may result in the overgrowth of non susceptible organisms
Pregnancy & Lactation
- US FDA pregnancy category: B
- Excreted in human milk: 1
- Caution in nursing women: 1
Precautions & Warnings
Use with care in patients receiving concurrent treatment with potent diuretics and with history of colitis. Cephalosporin antibiotics may in general be given safely to patients who are hypersensitive to penicillin although cross reactions have been reported
Therapeutic Class
Second generation Cephalosporins
Reconstitution
Different reconstitution volumes and methods for intramuscular and intravenous injection
Storage Conditions
Store in a cool, dry place (below 30°C), away from light and moisture. Keep out of the reach of children