Cefotil Plus 500 mg+125 mg (Tablet)

Unit Price: ৳ 60.00 (2 x 6: ৳ 720.00)

Strip Price: ৳ 360.00

Medicine Details

Category	Details
Generic	Cefuroxime axetil clavulanic acid
Company	Square pharmaceuticals plc
Also available as	Cefotil plus 250 mg tablet Cefotil plus 125 mg suspension

Indications

Treatment of pharyngitis/tonsillitis caused by Streptococcus pyogenes
Treatment of acute bacterial otitis media caused by Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis
Treatment of acute bacterial maxillary sinusitis caused by Streptococcus pneumoniae or Haemophilus influenzae
Treatment of lower respiratory tract infections including pneumonia caused by Streptococcus pneumoniae, Haemophilus influenzae, Klebsiella spp., Staphylococcus aureus, E. coli
Treatment of uncomplicated skin and skin-structure infections caused by Staphylococcus aureus or Streptococcus pyogenes
Treatment of uncomplicated urinary tract infections caused by E.coli or Klebsiella pneumoniae
Treatment of bone and joint infections caused by Staphylococcus aureus
Treatment of uncomplicated Gonorrhoea caused by Neisseria gonorrhoeae
Treatment of early Lyme Disease (erythema migrans) caused by Borrelia burgdorferi
Treatment of septicemia caused by Staphylococcus aureus, Streptococcus pneumoniae, E.coli, Haemophilus influenzae, Klebsiella spp.
Treatment of meningitis caused by Streptococcus pneumoniae, Haemophilus influenzae, Neisseria meningitidis, Staphylococcus aureus

Pharmacology

Bactericidal second generation cephalosporin antibiotic
Active against a wide range of Gram-positive and Gram-negative susceptible organisms
Inhibits bacterial cell wall synthesis by interfering with the transpeptidation process
Clavulanic acid is a beta lactamase inhibitor that provides protection from degradation by beta lactamase enzymes

Dosage & Administration

250 mg b.i.d. for adolescents and adults with pharyngitis/tonsillitis for 5-10 days
250 mg b.i.d. for adolescents and adults with acute bacterial maxillary sinusitis for 10 days
250-500 mg b.i.d. for adolescents and adults with acute bacterial exacerbation of chronic bronchitis for 10 days
250-500 mg b.i.d. for adolescents and adults with secondary bacterial infections of acute bronchitis for 5-10 days
250-500 mg b.i.d. for adolescents and adults with uncomplicated skin and skin structure infections for 10 days
250 mg b.i.d. for adolescents and adults with uncomplicated urinary tract infections for 7-10 days
1000 mg b.i.d. single dose for uncomplicated Gonorrhoea
250-500 mg b.i.d. for adolescents and adults with community acquired pneumonia for 5-10 days
500 mg b.i.d. for adolescents and adults with MDR Typhoid Fever for 10-14 days
500 mg b.i.d. for adolescents and adults with early Lyme disease for 20 days
Pediatric patients (3 months to 12 years) have specific dosages for various conditions

Interaction

Concomitant administration of probenecid with Cefuroxime-Clavulanic Acid increases the area under the serum concentration versus time curve by 50%. Drug that reduces gastric acidity may result in a lower bioavailability of Cefuroxime and tend to cancel the effect of postprandial absorption.

Contraindications

Patients with known allergy to cephalosporin
Patients with Pseudomembranous Colitis

Side Effects

Nausea
Vomiting
Diarrhea
Abdominal discomfort or pain
Prolonged administration may result in overgrowth of nonsusceptible microorganisms
Renal dysfunction
Anaphylaxis
Angioedema
Pruritis
Rash
Serum sickness like urticaria

Pregnancy & Lactation

Should be avoided in the first trimester if possible
Can be safely used in later pregnancy to treat urinary and other infections
Excreted into the breast milk in small quantities

Precautions & Warnings

Cefuroxime should be given with care to patients receiving concurrent treatment with potent diuretics and to patients with a history of colitis

Therapeutic Class

Second generation Cephalosporins

Storage Conditions

Store in a cool, dry place (below 30°C), away from light and moisture. Keep out of the reach of children.

Common Questions about Cefotil Plus 500 mg Tablet

Cefuroxime is the cephalosporin antibiotic and Clavulanic acid is a beta-lactamase inhibitor
Used to treat pharyngitis, tonsillitis, sinusitis, bronchitis, SSTI, UTI, gonorrhoea, pneumonia, typhoid fever
Starts working within 2-3 hours after taking it
Lasts for an average duration of 4-8 hours
Interaction with alcohol is unknown
No habit-forming tendencies were reported
Safe to use in pregnancy and breastfeeding