Secoclav 250 mg+62.5 mg (Tablet)

Unit Price: ৳ 34.50 (2 x 7: ৳ 483.00)

Strip Price: ৳ 241.50

Medicine Details

Category	Details
Generic	Cefuroxime axetil clavulanic acid
Company	General pharmaceuticals ltd
Also available as	Secoclav 500 mg tablet

Title

Secoclav 250 mg Tablet

Description

Secoclav 250 mg Tablet is a combination of Cefuroxime (a bactericidal second generation cephalosporin antibiotic) and Clavulanic acid (a beta-lactamase inhibitor). It is indicated for the treatment of various bacterial infections caused by sensitive bacteria.

Dosage & Administration

250 mg b.i.d. for 5-10 days for pharyngitis/tonsillitis
250 mg b.i.d. for 10 days for acute bacterial maxillary sinusitis
250-500 mg b.i.d. for 10 days for acute bacterial exacerbation of chronic bronchitis
250-500 mg b.i.d. for 5-10 days for secondary bacterial infections of acute bronchitis
250-500 mg b.i.d. for 10 days for uncomplicated skin and skin structure infections
250 mg b.i.d. for 7-10 days for uncomplicated urinary tract infections
1000 mg b.i.d. Single dose for uncomplicated gonorrhea
250-500 mg b.i.d. for 5-10 days for community-acquired pneumonia
500 mg b.i.d. for 10-14 days for MDR typhoid fever
500 mg b.i.d. for 20 days for early Lyme disease
20 mg/kg/day b.i.d for 5-10 days for pharyngitis/tonsillitis in pediatric patients
30 mg/kg/day b.i.d for 10 days for acute otitis media in pediatric patients
30 mg/kg/day b.i.d for 10 days for acute bacterial maxillary sinusitis in pediatric patients
30 mg/kg/day b.i.d for 10 days for impetigo in pediatric patients

Indications

Treatment of infections caused by sensitive bacteria including pharyngitis/tonsillitis caused by Streptococcus pyogenes
Acute Bacterial Otitis Media caused by Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis
Acute bacterial maxillary sinusitis caused by Streptococcus pneumoniae or Haemophilus influenzae
Lower respiratory tract infections including pneumoniae caused by Streptococcus pneumoniae, Haemophilus influenzae, Klebsiella spp., Staphylococcus aureus, E. coli
Acute bacterial exacerbation of chronic bronchitis and secondary bacterial infections of Acute bronchitis
Uncomplicated skin and skin-structure infections caused by Staphylococcus aureus or Streptococcus pyogenes
Uncomplicated urinary tract infections caused by E. coli or Klebsiella pneumoniae
Bone and Joint Infections caused by Staphylococcus aureus
Uncomplicated Gonorrhea caused by Neisseria gonorrhoeae
Early Lyme Disease (erythema migrans) caused by Borrelia burgdorferi
Septicemia caused by Staphylococcus aureus, Streptococcus pneumoniae, E.coli, Haemophilus influenzae, Klebsiella spp.
Meningitis caused by Streptococcus pneumoniae, Haemophilus influenzae, Neisseria meningitidis, Staphylococcus aureus
Switch therapy (Injectable to oral)

Pharmacology

Cefuroxime inhibits bacterial cell wall synthesis by interfering with the transpeptidation process. Clavulanic acid gives protection of Cefuroxime from degradation by beta lactamase enzymes.

Interaction

Concomitant administration of probenecid with Cefuroxime-Clavulanic Acid increases the area under the serum concentration versus time curve by 50%. Drug that reduces gastric acidity may result in a lower bioavailability of Cefuroxime.

Contraindications

Cefuroxime-Clavulanic Acid is contraindicated in patients with known allergy to cephalosporin & in patients with Pseudomembranous Colitis.

Side Effects

Nausea
Vomiting
Diarrhea
Abdominal discomfort or pain
Renal dysfunction
Anaphylaxis
Angioedema
Pruritis
Rash
Serum sickness like urticaria

Pregnancy & Lactation

Cefuroxime-Clavulanic Acid can be safely used in later pregnancy to treat urinary and other infections. It is excreted into the breast milk in small quantities.

Precautions & Warnings

Cefuroxime should be given with care to patients receiving concurrent treatment with potent diuretics & who have a history of colitis.

Therapeutic Class

Second generation Cephalosporins

Storage Conditions

Store in a cool, dry place (below 30°C), away from light and moisture. Keep out of the reach of children.

Common Questions

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Quick Tips: Take the medicine with food to avoid an upset stomach. Stop taking the medicine and inform your doctor immediately if you develop an itchy rash, swelling of the face, throat or tongue or breathing difficulties while taking it.