Xiclav 500 mg+125 mg (Tablet)

Title

• Xiclav 500 mg Tablet

Categories

• Pharmaceutical
• Medicine
• Antibiotic
• Infectious Disease Treatment

DosageForms

• Tablet

Indications

• Pharyngitis/Tonsillitis caused by Streptococcus pyogenes
• Acute Bacterial Otitis Media caused by Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis
• Acute bacterial maxillary sinusitis caused by Streptococcus pneumoniae or Haemophilus influenzae
• Lower respiratory tract infections including pneumoniae caused by Streptococcus pneumoniae, Haemophilus influenzae, Klebsiella spp., Staphylococcus aureus, E. coli
• Uncomplicated skin and skin-structure infections caused by Staphylococcus aureus, Streptococcus pyogenes
• Uncomplicated urinary tract infections caused by E.coli, Klebsiella pneumoniae
• Bone and Joint Infections caused by Staphylococcus aureus
• Uncomplicated Gonorrhoea caused by Neisseria gonorrhoeae
• Early Lyme Disease (erythema migrans) caused by Borrelia burgdorferi
• Septicemia caused by Staphylococcus aureus, E.coli, Haemophilus influenzae, Klebsiella spp.
• Meningitis caused by Streptococcus pneumoniae, Haemophilus influenzae, Neisseria meningitidis, Staphylococcus aureus

Pharmacology

• Bactericidal second generation cephalosporin antibiotic
• Interferes with bacterial cell wall synthesis
• Active against a wide range of Gram-positive and Gram-negative susceptible organisms
• Inhibits bacterial transpeptidation process
• Clavulanic acid is a naturally derived beta lactamase inhibitor produced by Streptomyces clavuligerus
• Clavulanic acid provides protection of Cefuroxime from degradation by beta lactamase enzymes

DosageAndAdministration

• 250 mg b.i.d. for 5-10 days for Pharyngitis/Tonsillitis in adults
• 250-500 mg b.i.d. for 5-10 days for Community acquired pneumonia in adults
• 20 mg/kg/day b.i.d. for 5-10 days for Pharyngitis/Tonsillitis in pediatric patients
• Cefuroxime-Clavulanic Acid tablet may be taken without regard to food

Interactions

• Concomitant administration of probenecid with Cefuroxime-Clavulanic Acid increases serum concentration
• Reduced bioavailability with drug that reduces gastric acidity

Contraindications

• Known allergy to cephalosporin
• Pseudomembranous Colitis

SideEffects

• Nausea
• Vomiting
• Diarrhea
• Abdominal discomfort or pain
• Prolonged administration may result in overgrowth of nonsusceptible microorganisms
• Renal dysfunction (rare)
• Anaphylaxis (rare)
• Angioedema (rare)
• Pruritis (rare)
• Rash (rare)

PregnancyAndLactation

• Safe for later pregnancy
• Excreted into breast milk in small quantities

PrecautionsAndWarnings

• Given with care to patients receiving concurrent treatment with potent diuretics
• Given with care to patients with history of colitis

TherapeuticClass

• Second generation Cephalosporins

StorageConditions

• Store in a cool, dry place below 30°C
• Away from light and moisture
• Keep out of the reach of children

CommonlyAskedQuestions

• What is Xiclav 500 mg Tablet?
• What is Xiclav 500 mg Tablet used for?
• How long does it take for Xiclav 500 mg Tablet to take effect?
• How long do the effects of this medicine last?
• Xiclav 500 mg Tablet it safe to consume alcohol while taking this medicine?
• Is Xiclav 500 mg Tablet a habit forming medicine?
• Can this medicine be taken during pregnancy?
• Can Xiclav 500 mg Tablet be taken while breast-feeding?

QuickTips

• Prescribed to treat bacterial infections
• Do not skip any doses and finish the full course of treatment
• Take with food to avoid an upset stomach
• Stop taking if itchy rash, swelling of the face, throat or tongue or breathing difficulties occur
• Do not use leftover medicine for treating any infection in the future

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