Cefixime-A 100 mg/5 ml (Powder for Suspension)

50 ml bottle: ৳ 210.00

Medicine Details

Category Details
Generic Cefixime trihydrate
Company Ad din pharmaceuticals ltd
Also available as
Cefixime a 200 mg capsule Cefixime a 400 mg capsule

Title

Cefixime-A 100 mg/5 ml Suspension

Categories

  • Antibiotics
  • Cephalosporins
  • Medication
  • Pharmacology
  • Therapeutic Class

Description

  • Indications:
    • Upper Respiratory Tract Infections (URTI)
    • Lower Respiratory Tract Infections
    • Urinary Tract Infections
  • Pharmacology: Bactericidal against a broad spectrum of gram positive and gram negative bacteria
  • Dosage & Administration:
    • Adults and children over 10 years: 200-400 mg daily
    • Elderly: Same dose as recommended for adults, dosage adjustment in severe renal impairment
    • Children: 8 mg/kg/day administered as a single dose or in two divided doses
    • In typhoid: 5 mg/kg body weight twice daily for 10-14 days
    • Dosage in Renal Impairment: Normal dose and schedule may be given in patients with creatinine clearances of 20 ml/min or greater
  • Interaction: Increases in prothrombin times noted in some patients receiving anticoagulant therapy
  • Contraindications: Known hypersensitivity to cephalosporin antibiotics
  • Side Effects:
    • Gastrointestinal disturbances:
      • Diarrhoea
      • Nausea
      • Abdominal pain
    • Central nervous system:
      • Headache
      • Dizziness
    • Hypersensitivity reactions:
      • Rash
      • Pruritis
      • Urticaria
    • Hematological and clinical chemistry:
      • Thrombocytopenia
      • Leukopenia
      • Eosinophilia
    • Miscellaneous:
      • Genital pruritis
      • Vaginitis
  • Pregnancy & Lactation: Use during pregnancy only if clearly needed, caution exercised when administered to a nursing woman
  • Precautions & Warnings:
    • Hypersensitivity to other drugs: Given with caution
    • Penicillin-sensitive patients: Given with caution
    • Markedly impaired renal function: Given with caution
    • Use in pregnancy and lactation: Not recommended
  • Overdose Effects: Gastric Lavage may be indicated; no specific antidote exists

Attribute list

  • Orally active
  • Bactericidal activity
  • Wide variety of Gram-positive and Gram-negative organisms
  • Marked in-vitro bactericidal activity
  • Highly stable in the presence of beta-lactamase enzymes
  • Third generation semisynthetic cephalosporin antibiotic
  • Interference in the synthesis of bacterial cell wall
  • 40%-50% absorption whether administered with or without food
  • Usual course of treatment is 7 days, may be continued for up to 14 days
  • Usual course of treatment is 7 days
  • Renal function assessment for dose adjustment
  • 40%-50% absorption whether administered with or without food
  • Interference in the synthesis of bacterial cell wall
  • Usual course of treatment is 7 days, may be continued for up to 14 days if required
  • Highly stable in the presence of Beta-lactamase enzyme
  • Alteration of normal flora of the colon
  • Clostridium difficile toxin as a primary cause of antibiotic-associated diarrhea
  • Absorption of Cefixime is not significantly modified by the presence of food
  • Increases in prothrombin times noted in some patients receiving anticoagulant therapy
  • Not recommended for patients with known hypersensitivity to cephalosporin antibiotics
  • Mild and self-limiting adverse reactions observed in clinical trials
  • Potential gastrointestinal disturbances
  • Potential central nervous system side effects
  • Potential hypersensitivity reactions
  • Potential hematological and clinical chemistry reactions
  • Genital pruritis and vaginitis reported as possible reactions
  • Use during pregnancy only if clearly needed
  • Caution exercised when administered to a nursing woman
  • Gastric Lavage may be indicated in case of overdose
  • No specific antidote for overdose
  • Storage at temperature below 30°C
  • Protected from light & moisture
  • Chemical Structure: C<sub>16</sub>H<sub>15</sub>N<sub>5</sub>O<sub>7</sub>S<sub>2</sub>
  • Molecular Formula: C<sub>16</sub>H<sub>15</sub>N<sub>5</sub>O<sub>7</sub>S<sub>2</sub>
  • Chemical Structure: [Chemical Structure Image Link]
  • Antibiotic used to treat bacterial infection
  • Prevention and treatment of conditions such as Urinary Tract Infection, Tonsillitis, Pharyngitis, and Bronchitis
  • Reported side effects include Diarrhea, Abdominal pain, Dark or clay-colored stools, Swelling, Dizziness, Heartburn, and Indigestion
  • Instructions for storage and disposal
  • Avoidance for treatment of viral infections like cold and flu
  • No need for special dietary instructions
  • Avoidance for treating diarrhoea
  • Safety not established for infants under 6 months
  • Not a penicillin variant
  • Diarrhoea is a known side effect, associated with higher doses only
  • No constipation associated with Cefixime-A 100 mg/5 ml Syrup
  • No evidence on interaction with contraception
  • No clinically proven interactions with Acetaminophen (Paracetamol)
  • Starts working after ingestion
  • Completion of the medication course is advised
  • Doctor consultation if no improvement after full course of treatment

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