Cephoral 100 mg/5 ml (Powder for Suspension)

37.5 ml bottle: ৳ 145.00

Medicine Details

Category Details
Generic Cefixime trihydrate
Company Labaid pharma ltd
Also available as
Cephoral 200 mg capsule Cephoral 400 mg capsule Cephoral ds 200 mg suspension Cephoral 25 mg pediatric drop

Brand Name

  • Cephoral 100 mg/5 ml Syrup

Therapeutic Class

  • Third generation Cephalosporins

Indications

  • Upper Respiratory Tract Infections
  • Lower Respiratory Tract Infections
  • Urinary Tract Infections

Mode of Action

  • Bactericidal against a broad spectrum of gram positive and gram negative bacteria

Dosage & Administration

  • Usual course of treatment is 7 days
  • Absorption not significantly modified by the presence of food
  • Recommended adult dosage is 200-400 mg daily
  • Recommended dosage for children is 8 mg/kg/day

Interaction

  • Increases in prothrombin times noted in a few patients

Contraindications

  • Known hypersensitivity to cephalosporin antibiotics

Side Effects

  • Commonly associated with gastrointestinal disturbances, central nervous system effects, and hypersensitivity reactions

Pregnancy & Lactation

  • Caution should be exercised when administered to a nursing woman
  • Use during pregnancy only if clearly needed

Precautions & Warnings

  • Given with caution to patients who have shown hypersensitivity to other drugs
  • Given with caution to penicillin-sensitive patients
  • Advised not to be used in pregnancy or in nursing mothers

Overdose Effects

  • Gastric Lavage may be indicated
  • No specific antidote exists
  • Not removed in significant quantities from the circulation by hemodialysis or peritoneal dialysis

Storage Conditions

  • Keep below 30°C temperature
  • Protected from light & moisture
  • Keep out of the reach of children

Chemical Structure

  • Molecular Formula: C16H15N5O7S2

Color Options

  • None

Dimensions

  • None

Age Group

  • Adults
  • Children over 10 years

Technical Specifications

  • Absorption of Cefixime is about 40-50% whether administered with or without food

Material

  • None

Design Elements

  • Orally active cephalosporin antibiotic

Usability Features

  • Highly stable in the presence of Beta-lactamase enzyme

Functions

  • Prevention of bacterial cell wall synthesis

Drug Class

  • Antibiotic

Gastrointestinal Disturbances

  • Diarrhoea, stool changes

Central Nervous System Effects

  • Headache, dizziness

Hypersensitivity Reactions

  • Rash, pruritis, urticaria, drug fever, arthralgia

Hematological and Clinical Chemistry Reactions

  • Thrombocytopenia, leukopenia, eosinophilia

Liver and Renal Function Tests Reactions

  • Mild transient changes observed

Miscellaneous Reactions

  • Genital pruritis, vaginitis

Indicated Infections

  • Otitis media
  • Bronchitis
  • Cystitis
  • Pyelonephritis

Renal Impairment Dosage

  • Administered in the presence of impaired renal function
  • Normal dose and schedule may be given in patients with creatinine clearances of 20 ml/min or greater
  • Dose not to exceed 200 mg once daily in patients with creatinine clearance less than 20 ml/min

Infected Pathogens

  • Streptococcus pneumonia
  • Escherichia coli
  • Klebsiella species
  • Haemophilus influenzae
  • Moraxella catarrhalis
  • Enterobacter species

Dosage in Typhoid

  • Recommended children dose is 5 mg/kg body weight twice daily for 10-14 days

Dosage for Children Aged Less Than 6 Months

  • Safety and efficacy not established

Dosage for Children Weighing More Than 50 kg or Older Than 10 Years

  • Administered with the recommended adult dose 200-400 mg daily

Dosage for Elderly

  • May be given the same dose as recommended for adults
  • Dosage should be adjusted in severe renal impairment

Dosage for Children 1-10 Years

  • Daily doses in terms of volume of suspension suggested

Dietary Instructions

  • Continue normal diet unless instructed otherwise by the doctor

Antidote

  • No specific antidote exists

Availability

  • Oral administration

Stability

  • Highly stable in the presence of Beta-lactamase enzyme

Bacterial Susceptibility

  • Many organisms resistant to penicillins and some cephalsporins may be susceptible to Cefixime

Absorption

  • About 40-50% whether administered with or without food

Disposal Instructions

  • Proper disposal of expired and unused medications is important to avoid health problems

Onset of Action

  • Starts working as soon after ingestion

Complete Course

  • Advised to complete the medication course for the suggested days

Duration of Treatment

  • May be continued for up to 14 days if required

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