Duracef 400 mg (Capsule)

Unit Price: ৳ 55.00 (2 x 6: ৳ 660.00)
Strip Price: ৳ 330.00

Medicine Details

Category Details
Generic Cefixime trihydrate
Company Navana pharmaceuticals ltd
Also available as
Duracef 200 mg capsule Duracef 100 mg suspension Duracef ds 200 mg suspension Duracef 25 mg pediatric drop Duracef max 500 mg suspension

Indications

  • Treatment of upper respiratory tract infections (URTI)
  • Treatment of lower respiratory tract infections
  • Treatment of urinary tract infections (UTI)
  • Highly stable in the presence of beta-lactamase enzymes

Pharmacology

  • Third generation semisynthetic cephalosporin antibiotic
  • Bactericidal against a broad spectrum of gram positive and gram negative bacteria
  • Interferes in the synthesis of bacterial cell wall
  • Highly stable in the presence of Beta-lactamase enzyme

Dosage & Administration

  • Usual course of treatment is 7 days, can be extended up to 14 days if required
  • Recommended adult dosage is 200-400 mg daily for severity of infection
  • Dosage for children based on weight and age
  • Dosage adjustments needed for elderly and patients with renal impairment

Interaction

  • May increase prothrombin times in patients on anticoagulant therapy

Contraindications

  • Contraindicated in patients with known hypersensitivity to cephalosporin antibiotics

Side Effects

  • Commonly seen side effects include diarrhea, nausea, abdominal pain, headache, dizziness, rash, thrombocytopenia
  • Mild and self-limiting adverse reactions observed in clinical trials

Pregnancy & Lactation

  • Limited data on use during pregnancy, caution advised
  • Not known whether excreted in human milk, caution advised for nursing women

Precautions & Warnings

  • Caution advised in patients with hypersensitivity to other drugs
  • Partial cross-allergenicity between penicillins and cephalosporins
  • Caution in patients with renal impairment and on penicillin-sensitive patients

Overdose Effects

  • Gastric lavage may be indicated in case of overdose
  • No specific antidote available
  • Adverse reactions similar to recommended doses reported in healthy adult volunteers

Therapeutic Class

  • Belongs to the class of third generation Cephalosporins

Storage Conditions

  • Store below 30°C, protected from light and moisture
  • Keep out of reach of children

Chemical Structure

  • Molecular Formula: C16H15N5O7S2

Popular Questions

  • What is Duracef 400 mg Capsule used for?
  • What are the common side effects of Duracef 400 mg Capsule?
  • How should Duracef 400 mg Capsule be stored and disposed?
  • Does Duracef 400 mg Capsule work for cold and flu?
  • Is Duracef 400 mg Capsule safe for infants?
  • Does Duracef 400 mg Capsule interact with contraception?
  • Can Duracef 400 mg Capsule cause constipation?

Dosage in Renal Impairment

  • Normal dose for creatinine clearances of 20 ml/min or greater
  • Dose adjustment required for creatinine clearance less than 20 ml/min
  • Recommendations for patients on chronic ambulatory peritoneal dialysis or hemodialysis

Absorption

  • About 40-50% absorption rate with or without food

Chemical Structure Image

  • Image of Chemical Structure available

Common Questions

  • Important questions and answers regarding the usage of Duracef 400 mg Capsule

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