Rofixim 400 mg (Capsule)
Unit Price: ৳ 72.00 (2 x 5: ৳ 720.00)
Strip Price: ৳ 360.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Cefixime trihydrate |
| Company | Radiant pharmaceuticals ltd |
| Also available as |
Indications
- Treatment of upper respiratory tract infections (URTI)
- Treatment of lower respiratory tract infections
- Treatment of urinary tract infections (UTI) such as cystitis, cystourethritis, pyelonephritis
- Effective against Streptococcus pneumoniae
- Effective against Streptococcus pyogenes
- Effective against Escherichia coli
- Effective against Proteus mirabilis
- Effective against Klebsiella species
- Effective against Haemophilus influenzae (beta-lactamase positive and negative)
- Effective against Moraxella catarrhalis (beta-lactamase positive and negative)
- Highly stable in the presence of beta-lactamase enzymes
Pharmacology
- Bactericidal against a broad spectrum of gram-positive and gram-negative bacteria
- Interferes with the synthesis of bacterial cell wall
- Highly stable in the presence of Beta-lactamase enzyme
- Absorption is about 40% to 50% whether administered with or without food
Dosage & Administration
- Usual course of treatment is 7 days
- Recommended adult dosage is 200-400 mg daily
- Dose can be given as a single dose or in two divided doses
- Dosage for children is 8 mg/kg/day
- Different daily doses for children based on age and weight
- Recommended children dose for typhoid is 5 mg/kg body weight twice daily for 10-14 days
- Special precautions for dosage in renal impairment
- No established safety and efficacy for children aged less than 6 months
Interaction
- Increases in prothrombin times have been noted in a few patients
- Care should be taken in patients receiving anticoagulant therapy
Contraindications
- Known hypersensitivity to cephalosporin antibiotics
Side Effects
- Most adverse reactions observed in clinical trials were mild and self-limiting
- Common gastrointestinal disturbances such as diarrhea and stool changes
- Other gastrointestinal side effects like nausea, abdominal pain, dyspepsia
- Central nervous system side effects including headache and dizziness
- Hypersensitivity reactions in the form of rash, pruritus, urticaria
- Hematological and clinical chemistry disturbances such as thrombocytopenia, leukopenia
- Mild transient change in liver and renal function tests
- Other possible reactions include genital pruritus and vaginitis
Pregnancy & Lactation
- No adequate and well-controlled studies in pregnant women
- Use during pregnancy only if clearly needed
- Caution should be exercised when administered to a nursing woman
Precautions & Warnings
- Given with caution to patients showing hypersensitivity to other drugs
- Caution advised for penicillin-sensitive patients
- Administration with caution in patients with markedly impaired renal function
- Treatment alters normal flora of the colon and may permit overgrowth of clostridia
- Not recommended in pregnancy or nursing mothers unless essential
Overdose Effects
- Gastric Lavage may be indicated
- No specific antidote exists
- Not removed in significant quantities by hemodialysis or peritoneal dialysis
Therapeutic Class
- Third generation Cephalosporins
Storage Conditions
- Keep below 30°C temperature
- Protected from light & moisture
- Keep out of the reach of children
Chemical Structure
- Molecular Formula: C16H15N5O7S2
Common Questions
- What is Rofixim 400 mg Capsule?
- What are the uses of Rofixim 400 mg Capsule?
- What are the Side Effects of Rofixim 400 mg Capsule?
- What are the instructions for storage and disposal Rofixim 400 mg Capsule?
- Will Rofixim 400 mg Capsule work for treating cold and flu?
- Is there any special dietary instruction which I should follow?
- Is Rofixim 400 mg Capsule can be used to treat diarrhoea?
- Is it safe to give Rofixim 400 mg Capsule to infants?
- Does Rofixim 400 mg Capsule is a penicillin variant?
- Does Rofixim 400 mg Capsule cause loose-motion?
- Is constipation associated with Rofixim 400 mg Capsule?
- Does Rofixim 400 mg Capsule interact with contraception?
- Can I take acetaminophen along with Rofixim 400 mg Capsule?
- How long does Rofixim 400 mg Capsule take to work?
- What if I do not get better after using Rofixim 400 mg Capsule?