Truso 400 mg (Capsule)

Indications

• Treatment of upper respiratory tract infections
• Treatment of lower respiratory tract infections
• Treatment of urinary tract infections
• Bactericidal activity against Gram-positive organisms
• Bactericidal activity against Gram-negative organisms
• Effective against Streptococcus pneumonia
• Effective against Streptococcus pyogenes
• Effective against Escherichia coli
• Effective against Proteus mirabilis
• Effective against Klebsiella species
• Effective against Haemophilus influenzae
• Effective against Moraxella catarrhalis
• Effective against Enterobacter species
• Marked in-vitro bactericidal activity
• High stability in the presence of beta-lactamase enzymes

Pharmacology

• Third generation semisynthetic cephalosporin antibiotic
• Oral administration
• Bactericidal against broad spectrum of bacteria
• Interferes with bacterial cell wall synthesis
• Highly stable in the presence of beta-lactamase enzyme
• About 40-50% absorption with or without food

Dosage & Administration

• Usual course of treatment is 7 days
• May be continued for up to 14 days if required
• Recommended adult dosage is 200-400 mg daily
• Dosage adjustment for elderly and children
• Dosage based on severity of infection
• Dosage adjustment in severe renal impairment

Interaction

• Increases in prothrombin times noted in few patients
• Care required in patients receiving anticoagulant therapy

Contraindications

• Known hypersensitivity to cephalosporin antibiotics

Side Effects

• Mild and self-limiting adverse reactions observed in clinical trials
• Gastrointestinal disturbances
• Diarrhoea
• Nausea
• Headache
• Dizziness
• Allergic reactions
• Thrombocytopenia
• Leukopenia
• Eosinophilia
• Mild transient change in liver and renal function tests

Pregnancy & Lactation

• No adequate and well-controlled studies in pregnant women
• Caution advised in pregnancy
• Not known to be excreted in human milk
• Caution advised in lactating women

Precautions & Warnings

• Caution advised in patients with hypersensitivity to other drugs
• Caution advised in penicillin-sensitive patients
• Caution advised in patients with markedly impaired renal function
• Alters normal flora of the colon
• May permit overgrowth of clostridia

Overdose Effects

• Gastric Lavage may be indicated
• No specific antidote exists
• Not removed in significant quantities by hemodialysis or peritoneal dialysis

Therapeutic Class

• Third generation Cephalosporins

Storage Conditions

• Keep below 30°C temperature
• Protected from light & moisture
• Keep out of the reach of children

Chemical Structure

• Molecular Formula: C16H15N5O7S2

Common Questions about Truso 400 mg Capsule

• Bacterial infection treatment
• Prevention from conditions such as Urinary Tract Infection, Tonsillitis, Pharyngitis, and Bronchitis
• Side effects, storage, and disposal instructions
• Ineffectiveness for cold and flu treatment
• Special dietary instructions
• Safety for infants
• Penicillin variant status
• Interaction with contraception
• Interaction with acetaminophen
• Time to work and actions if not getting better
• Quick tips for usage

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