Cefot 250 mg/5 ml (IM/IV Injection)

250 mg vial: ৳ 50.15

Medicine Details

Category Details
Generic Cefotaxime
Company Aci limited
Also available as
Cefot 500 mg injection Cefot 1 gm injection

Title

  • Cefotaxime

Categories

  • Antibiotic
  • Medication
  • Pharmaceutical

Description

  • Cefotaxime is indicated for the treatment of various infections caused by bacteria of established sensitivity, such as septicaemia, respiratory tract infections, urinary tract infections, soft-tissue infections, bone and joint infections, obstetric and gynaecological infections, gonorrhoea, and others.
  • Cefotaxime is a broad spectrum bactericidal 3rd generation parenteral cephalosporin antibiotic, exceptionally active against gram-negative organisms sensitive or resistant to first or second generation cephalosporins, and similar to other cephalosporins in activity against gram-positive bacteria.
  • The recommended dosage for adults with mild to moderate infections is 1 gm every 12 hours, while for children it is 100-150 mg/kg/day in 2 to 4 divided doses. Dosage adjustments are necessary for severe infections, sensitive Pseudomonas spp., and gonorrhoea.
  • Cefotaxime is contraindicated in patients with hypersensitivity to cefotaxime or cephalosporin antibiotics, and caution should be exercised in individuals with a history of gastrointestinal disease, particularly colitis, and in patients with renal impairment.

Indications

  • Septicaemia
  • Respiratory Tract Infections
  • Urinary Tract Infections
  • Soft-tissue Infections
  • Bone and Joint Infections
  • Obstetric and Gynaecological Infections
  • Gonorrhoea
  • Other Bacterial Infections
  • Prophylaxis

Mode of action

  • Binds to penicillin binding proteins (PBPs)
  • Inhibits transpeptidation step of peptidoglycan synthesis
  • Inhibits biosynthesis and arrests cell wall assembly
  • Results in bacterial cell death
  • Broad spectrum bactericidal 3rd generation cephalosporin antibiotic

Dosage and Administration

  • Recommended dosage for adults is 1 gm every 12 hours for mild to moderate infections
  • Dosage may be varied according to the severity of infection, sensitivity of causative organisms, and patient condition
  • Higher doses may be required for severe infections and sensitive Pseudomonas
  • Usual dosage range for children is 100-150 mg/kg/day in 2 to 4 divided doses
  • Dosage adjustments may be necessary for gonorrhoea and in neonates

Interaction

  • Increased nephrotoxicity with concomitant administration of cephalosporins and aminoglycoside antibiotics

Contraindications

  • Hypersensitivity to cefotaxime or cephalosporin antibiotics

Side Effects

  • Candidiasis
  • Rashes
  • Fever
  • Transient rises in liver transaminase and/or alkaline phosphatase
  • Diarrhoea
  • Pseudomembranous colitis
  • Changes in renal function
  • Hypersensitivity reactions

Pregnancy and Lactation

  • Not established safety in human pregnancy
  • Excreted in the milk

Precautions and Warnings

  • Caution in individuals with a history of gastrointestinal disease, particularly colitis
  • Dosage adjustments for patients with transient or persistent reduction of urinary output due to renal insufficiency
  • No clinical evidence supporting the necessity of changing the dosage in patients with renal dysfunction

Use in Special Populations

  • Dosage adjustments in renal impairment

Therapeutic Class

  • Third generation Cephalosporins

Storage Conditions

  • Store below 25°C
  • Protected from light and moisture
  • Reconstituted solution is stable for up to 24 hours if stored between 2°C to 8°C

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