Cefot 250 mg/5 ml (IM/IV Injection)
250 mg vial: ৳ 50.15
Medicine Details
| Category | Details |
|---|---|
| Generic | Cefotaxime |
| Company | Aci limited |
| Also available as |
Title
- Cefotaxime
Categories
- Antibiotic
- Medication
- Pharmaceutical
Description
- Cefotaxime is indicated for the treatment of various infections caused by bacteria of established sensitivity, such as septicaemia, respiratory tract infections, urinary tract infections, soft-tissue infections, bone and joint infections, obstetric and gynaecological infections, gonorrhoea, and others.
- Cefotaxime is a broad spectrum bactericidal 3rd generation parenteral cephalosporin antibiotic, exceptionally active against gram-negative organisms sensitive or resistant to first or second generation cephalosporins, and similar to other cephalosporins in activity against gram-positive bacteria.
- The recommended dosage for adults with mild to moderate infections is 1 gm every 12 hours, while for children it is 100-150 mg/kg/day in 2 to 4 divided doses. Dosage adjustments are necessary for severe infections, sensitive Pseudomonas spp., and gonorrhoea.
- Cefotaxime is contraindicated in patients with hypersensitivity to cefotaxime or cephalosporin antibiotics, and caution should be exercised in individuals with a history of gastrointestinal disease, particularly colitis, and in patients with renal impairment.
Indications
- Septicaemia
- Respiratory Tract Infections
- Urinary Tract Infections
- Soft-tissue Infections
- Bone and Joint Infections
- Obstetric and Gynaecological Infections
- Gonorrhoea
- Other Bacterial Infections
- Prophylaxis
Mode of action
- Binds to penicillin binding proteins (PBPs)
- Inhibits transpeptidation step of peptidoglycan synthesis
- Inhibits biosynthesis and arrests cell wall assembly
- Results in bacterial cell death
- Broad spectrum bactericidal 3rd generation cephalosporin antibiotic
Dosage and Administration
- Recommended dosage for adults is 1 gm every 12 hours for mild to moderate infections
- Dosage may be varied according to the severity of infection, sensitivity of causative organisms, and patient condition
- Higher doses may be required for severe infections and sensitive Pseudomonas
- Usual dosage range for children is 100-150 mg/kg/day in 2 to 4 divided doses
- Dosage adjustments may be necessary for gonorrhoea and in neonates
Interaction
- Increased nephrotoxicity with concomitant administration of cephalosporins and aminoglycoside antibiotics
Contraindications
- Hypersensitivity to cefotaxime or cephalosporin antibiotics
Side Effects
- Candidiasis
- Rashes
- Fever
- Transient rises in liver transaminase and/or alkaline phosphatase
- Diarrhoea
- Pseudomembranous colitis
- Changes in renal function
- Hypersensitivity reactions
Pregnancy and Lactation
- Not established safety in human pregnancy
- Excreted in the milk
Precautions and Warnings
- Caution in individuals with a history of gastrointestinal disease, particularly colitis
- Dosage adjustments for patients with transient or persistent reduction of urinary output due to renal insufficiency
- No clinical evidence supporting the necessity of changing the dosage in patients with renal dysfunction
Use in Special Populations
- Dosage adjustments in renal impairment
Therapeutic Class
- Third generation Cephalosporins
Storage Conditions
- Store below 25°C
- Protected from light and moisture
- Reconstituted solution is stable for up to 24 hours if stored between 2°C to 8°C