Cefot 1 gm/10 ml (IM/IV Injection)

1 gm vial: ৳ 132.40

Medicine Details

Category Details
Generic Cefotaxime
Company Aci limited
Also available as
Cefot 250 mg injection Cefot 500 mg injection

Title

Cefotaxime Injection

Categories

  • Antibiotic
  • Medication
  • Pharmaceutical

Description

Cefotaxime is indicated for the treatment of various infections caused by bacteria of established sensitivity. It is a 3rd generation parenteral cephalosporin antibiotic with broad-spectrum bactericidal activity.

Indications

  • Septicaemia
  • Respiratory Tract Infections
  • Urinary Tract Infections
  • Soft-tissue Infection
  • Bone and Joint Infections
  • Obstetric and Gynaecological Infections
  • Gonorrhoea
  • Bacterial Meningitis
  • Prophylaxis for Post-operative Infections

Pharmacology

Cefotaxime binds to penicillin binding proteins, inhibiting peptidoglycan synthesis and resulting in bacterial cell death. It is exceptionally active against gram-negative organisms and has activity against gram-positive bacteria.

Dosage and administration

Adults: 1 gm every 12 hours for mild to moderate infections. Children: 100-150 mg/kg/day in 2 to 4 divided doses. Neonates: 50 mg/kg/day in 2 to 4 divided doses. Gonorrhoea: 500 mg as a single dose.

Interaction

Increased nephrotoxicity may occur when cephalosporins are administered concomitantly with aminoglycoside antibiotics.

Contraindications

Cefotaxime is contraindicated in patients with known hypersensitivity to cefotaxime or cephalosporin antibiotics.

Side effects

  • Candidiasis
  • Rashes
  • Fever
  • Transient rises in liver transaminase
  • Diarrhoea
  • Pseudomembranous colitis
  • Changes in renal function
  • Hypersensitivity reactions

Pregnancy and lactation

The safety of Cefotaxime in human pregnancy has not been established. It is excreted in breast milk.

Precautions and warnings

Prescribe with caution in individuals with a history of gastrointestinal disease, particularly colitis. Dosage adjustment is necessary in patients with renal impairment.

Special populations

  • Renal impairment: Dosage adjustment is necessary in severe renal failure. Further adjustment may be required in all other patients according to the course of infection.

Therapeutic class

Third generation Cephalosporins

Storage conditions

Store below 25°C, protected from light and moisture. Reconstituted solution is stable for up to 24 hours if stored between 2°C to 8°C.

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