Taxceph 1 gm/10 ml (IM/IV Injection)
1 gm vial: ৳ 140.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Cefotaxime |
| Company | Ibn sina pharmaceuticals ltd |
| Also available as |
Title
- Taxceph Cefotaxime Injection
Categories
- Medicine
- Pharmaceuticals
- Antibiotics
- Cephalosporins
Description
- Broad-spectrum bactericidal 3rd generation parenteral cephalosporin antibiotic
- Indicated for various infections such as respiratory tract, urinary tract, soft-tissue, bone and joint, obstetric and gynaecological, gonorrhoea, and prophylaxis
- Pharmacologically inhibits bacterial cell wall assembly leading to cell death
- Dosage varies for adults, children, neonates, and in gonorrhoea
- Interaction with aminoglycoside antibiotics may increase nephrotoxicity
- Contraindicated in patients with hypersensitivity to cefotaxime or cephalosporin antibiotics
- Mild and transient side effects reported including candidiasis, rashes, fever, liver enzyme changes, diarrhea, pseudomembranous colitis, and renal function changes
- Use with caution in pregnancy and lactation, and in individuals with gastrointestinal disease or renal impairment
- Therapeutic class: Third generation Cephalosporins
- Storage conditions: Below 25°C, protected from light and moisture, reconstituted solution stable for up to 24 hours if stored between 2°C to 8°C
Infections Indicated
- Septicaemia
- Respiratory Tract Infections
- Urinary Tract Infections
- Soft-tissue Infection
- Bone and Joint Infections
- Obstetric and Gynaecological Infections
- Gonorrhoea
- Prophylaxis
Pharmacology
- Binds to penicillin binding proteins to inhibit bacterial cell wall synthesis
Dosage and Administration for Adults
- Recommended dosage for mild to moderate infections: 1 gm every 12 hours
- Dosage may vary according to severity of infection, causative organisms' sensitivity, and patient's condition
- Severe infections: dosage may be increased up to 12 gm daily in 3 or 4 divided doses
- Greater than 6 gm daily doses may be required for infections caused by sensitive Pseudomonas spp.
Dosage and Administration for Children
- Usual dosage range: 100-150 mg/kg/day in 2 to 4 divided doses
- Up to 200 mg/kg/day doses may be required in very severe infections
Dosage and Administration for Neonates
- Recommended dosage: 50 mg/kg/day in 2 to 4 divided doses
- In severe infections: 150-200 mg/kg/day in divided doses
Dosage in Gonorrhoea
- 500 mg as a single dose
Interaction
- Concomitant administration with aminoglycoside antibiotics may increase nephrotoxicity
Contraindications
- Hypersensitivity to cefotaxime or cephalosporin antibiotics
Side Effects
- Relatively infrequent and mild adverse reactions reported
- Effects include candidiasis, rashes, fever, liver enzyme changes, diarrhea, pseudomembranous colitis, renal function changes, and hypersensitivity reactions such as skin rashes, drug fever, and anaphylaxis
Pregnancy and Lactation
- Safety in human pregnancy not established
- Excreted in the milk
Precautions and Warnings
- Prescribed with caution in individuals with a history of gastrointestinal disease, particularly colitis
- Dosage reduction needed in patients with transient or persistent reduction of urinary output due to renal insufficiency
- No clinical evidence supporting the necessity of changing the dosage in patients with renal dysfunction
Use in Special Populations
- Dosage reduction necessary in severe renal failure
- Adjustment of dosage may be required according to the course of infection and the general condition of the patient
Storage Conditions
- Store below 25°C, protected from light and moisture
- Reconstituted solution stable for up to 24 hours if stored between 2°C to 8°C
Therapeutic Class
- Third generation Cephalosporins