Taxim 250 mg/5 ml (IM/IV Injection)

250 mg vial: ৳ 75.22

Medicine Details

Category	Details
Generic	Cefotaxime
Company	Acme laboratories ltd
Also available as	Taxim 500 mg injection Taxim 1 gm injection

Title

Taxim 1g Injection

Description

Taxim is indicated for the treatment of various infections, such as respiratory tract infections, urinary tract infections, soft-tissue infections, bone and joint infections, obstetric and gynecological infections, gonorrhea, and other bacterial infections. It can also be used for prophylaxis in certain surgical procedures.

Color Options

Clear solution for injection

Dosage Form

Injection

Volume

Pharmacology

Binds to penicillin binding proteins to inhibit peptidoglycan synthesis, resulting in bacterial cell death
Broad spectrum bactericidal 3rd generation parenteral cephalosporin antibiotic
Active against gram-negative organisms sensitive or resistant to first or second generation cephalosporins
Activity against gram-positive bacteria

Recommended Dosage for Adults

1 gm every 12 hourly for mild to moderate infections; dosage may be varied according to severity of infection, sensitivity of causative organisms, and patient's condition

Recommended Dosage for Children

100-150 mg/kg/day in 2 to 4 divided doses; up to 200 mg/kg/day may be required for very severe infections

Recommended Dosage for Neonates

50 mg/kg/day in 2 to 4 divided doses; 150-200 mg/kg/day in divided doses for severe infections

Dosage in Gonorrhea

500 mg as a single dose

Interaction

Increased nephrotoxicity reported with concomitant administration of cephalosporins and aminoglycoside antibiotics

Contraindications

Hypersensitivity to cefotaxime or the cephalosporin group of antibiotics

Side Effects

Candidiasis
Rashes
Fever
Transient rises in liver transaminase and/or alkaline phosphatase
Diarrhea
Pseudomembranous colitis
Changes in renal function
Hypersensitivity reactions including skin rashes, drug fever, and rarely anaphylaxis

Pregnancy & Lactation

Safety not established in human pregnancy; excreted in the milk

Precautions & Warnings

Prescribed with caution in individuals with a history of gastrointestinal disease, particularly colitis
Dosage reduction required in patients with transient or persistent reduction of urinary output due to renal insufficiency
No clinical evidence supporting the necessity of changing the dosage in patients with profound renal dysfunction

Dosage in Renal Impairment

Reduce the dosage of Taxim in severe renal failure; further dosage adjustment may be required in all other patients according to the course of infection and the general condition of the patient