CP 40 mg/5 ml (Powder for Suspension)

50 ml bottle: ৳ 98.65

Medicine Details

Category	Details
Generic	Cefpodoxime proxetil
Company	Acme laboratories ltd
Also available as	Cp 20 mg pediatric drop

Title

Cefpodoxime Proxetil

Description

Cefpodoxime Proxetil is an oral 3rd generation cephalosporin, indicated for the treatment of infections caused by susceptible microorganisms. It has good stability to beta lactamases and activity against a wide range of gram-positive and gram-negative bacteria.

Color options

White

Dimensions

Standard medicine bottle size

Functions

Treatment of acute otitis media
Treatment of pharyngitis/tonsillitis
Treatment of maxillary sinusitis
Treatment of community-acquired pneumonia
Treatment of bacterial exacerbation of chronic bronchitis
Treatment of skin and skin structure infections
Treatment of uncomplicated urinary tract infections
Treatment of uncomplicated gonorrhea
Reconstitution into suspension for oral administration

Materials

Cefpodoxime
Proxetil
Active metabolite Cefpodoxime
Sodium bicarbonate
Aluminium hydroxide

Technical specifications

Oral 3rd generation cephalosporin
Approximately 29 to 33% of Cefpodoxime excreted unchanged in the urine in 12 hours
High stability in presence of beta-lactamase enzyme
Activity against a wide range of gram-positive & gram-negative bacteria
Dosage adjustments for patients with renal dysfunction

Design elements

Bottle with clear dosage instructions
Reconstituted suspension should be stored in the refrigerator
Instruction to shake the suspension well before each use

Usability features

For oral administration
Dosage and administration details provided for different age groups
Interaction information with other drugs and compounds
Precautions and warnings for specific patient conditions

Interaction

Reduced plasma level with antacids
Inhibited renal excretion by probenecid
Nephrotoxic potential monitoring advised

Dosage administration

Adults adolescents:
- Pharyngitis/tonsillitis: 100 mg 12 hourly, 5 to 10 days
- Acute maxillary sinusitis: 200 mg 12 hourly, 10 days
- Community-acquired pneumonia: 200 mg 12 hourly, 14 days
- Acute bacterial exacerbations of chronic bronchitis: 200 mg 12 hourly, 10 days
- Skin and skin structure: 400 mg 12 hourly, 7 to 14 days
- Uncomplicated urinary tract infection: 100 mg 12 hourly, 7 days
- Uncomplicated gonorrhea: single dose of 200 mg
- Rectal gonococcal infections in women: single dose of 200 mg
Infants pediatric patients:
- Acute otitis media: 5 mg/kg body weight 12 hourly, 5 days
- Pharyngitis /tonsillitis: 5 mg/kg body weight 12 hourly, 5 to 10 days
- Acute maxillary sinusitis: 5 mg/kg body weight 12 hourly, 10 days
Patients renal dysfunction: Dosing intervals should be increased to 24 hourly for severe renal impairment (creatinine clearance <30ml/min)

Contraindications

Known allergy to Cefpodoxime or cephalosporin group of antibiotics

Side effects

Diarrhea
Nausea
Skin & vaginal fungal infection
Abdominal pain
Headache
Chest pain
Myalgia
Dyspepsia
Dizziness
Vertigo
Cough
Incidence of fungal skin rash is more in children

Pregnancy lactation

Not teratogenic or embryocidal in animal trial
No adequate and well-controlled study in pregnant women
Excreted in human milk, decision should be made whether to discontinue breastfeeding or discontinue the drug

Precautions warnings

Caution in patients with reduced urinary output due to renal insufficiency
Administer with caution to patients receiving concurrent treatment with potent diuretics
Prolonged use may result in overgrowth of non-susceptible organisms
Repeated evaluation of the patient’s condition is essential

Therapeutic class

Third generation Cephalosporins

Reconstitution

Reconstitute into suspension for oral administration by adding water to the dry mixture in the bottle and shaking well

Storage conditions

Keep in a dry place away from light and heat. Keep out of the reach of children