Lesero 250 mg/vial (IM/IV Injection)

250 mg vial: ৳ 70.00

Medicine Details

Category Details
Generic Ceftazidime pentahydrate
Company Ziska pharmaceuticals ltd
Also available as
Lesero 1 gm injection Lesero 500 mg injection

Title

Lesero Injection

Categories

  • Medicine
  • Pharmaceutical

Description

Lesero Injection is indicated for the treatment of patients with infections caused by susceptible strains of the designated organisms in various diseases such as lower respiratory tract infections, skin and skin structure infections, urinary tract infections, bacterial septicemia, bone and joint infections, gynecologic infections, intraabdominal infections, and central nervous system infections.

Indications

  • Lower Respiratory Tract Infections
  • Skin and Skin Structure Infections
  • Urinary Tract Infections
  • Bacterial Septicemia
  • Bone and Joint Infections
  • Gynecologic Infections
  • Intraabdominal Infections
  • Central Nervous System Infections

Pharmacology

Ceftazidime is a semisynthetic, broad-spectrum, beta-lactam antibiotic for parenteral administration that inhibits cell-wall synthesis and is active against gram-negative and gram-positive organisms.

Dosage

  • UsualAdultDosage: 1 gram administered intravenously or intramuscularly every 8 to 12 hours
  • AdultDosageRange:
    • 1 to 6 gm per day 8 or 12 hourly (IM/IV)
    • 500 mg or 1 gm 12 hourly for urinary tract infections
    • 2 gm 8 or 12 hourly for severe infections or immunocompromised patients
  • ElderlyDosage: Should not exceed 3 gm daily, especially in those over 80 years of age
  • PediatricDosage: 30 to 100 mg/kg/day for children aged over two months, up to 150 mg/kg/day for infected immunocompromised or fibrocystic children or children with meningitis
  • NeonatesAndChildrenDosage: 25 to 60 mg/kg/day as two divided doses

Administration

Ceftazidime may be given intravenously or by deep IM injection and should be reconstituted with the supplied Sterile Water for Injection.

Contraindications

  • Hypersensitivity to Ceftazidime or cephalosporin group of antibiotics

SideEffects

  • Local reactions following IV injection
  • Allergic reactions
  • Gastrointestinal reactions
  • Hypersensitivity reactions
  • Central nervous system reactions

PregnancyAndLactation

  • Pregnancy: Use only if clearly needed with caution
  • Lactation: Consider discontinuing nursing or the drug, taking into account the importance of the drug to the mother

PrecautionsAndWarnings

  • Reduce total daily dosage for patients with renal insufficiency
  • Prescribe with caution in individuals with a history of gastrointestinal disease

UseInSpecialPopulations

  • ImpairedRenalFunction: Dosage reduction for glomerular filtration rate <50 mL/min
  • DosageInPeritonealDialysis: May also be used in peritoneal dialysis and continuous ambulatory peritoneal dialysis (CAPD)
  • ImpairedHepaticFunction: No adjustment in dosage required

OverdoseEffects

Careful observation and supportive treatment for reactions such as seizure activity, encephalopathy, neuromuscular excitability

TherapeuticClass

Third generation Cephalosporins

Reconstitution

Amount of WFI to be added for IM and IV administration

StorageConditions

Store below 25°C, protected from light and moisture, reconstituted solutions are stable for up to 24 h if stored between 2°C-8°C

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