Trizidim 250 mg/vial (IM/IV Injection)

250 mg vial: ৳ 70.47

Medicine Details

Category Details
Generic Ceftazidime pentahydrate
Company Acme laboratories ltd
Also available as
Trizidim 500 mg injection Trizidim 1 gm injection

Indications

  • Treatment of lower respiratory tract infections
  • Treatment of skin and skin structure infections
  • Treatment of urinary tract infections
  • Treatment of bacterial septicemia
  • Treatment of bone and joint infections
  • Treatment of gynecologic infections
  • Treatment of intraabdominal infections
  • Treatment of central nervous system infections

Pharmacology

  • Semisynthetic beta-lactam antibiotic
  • Bactericidal action
  • Inhibition of enzymes responsible for cell-wall synthesis
  • Susceptible to a wide range of gram-negative organisms
  • Stability to most clinically important beta-lactamases

Dosage

  • Usual adult dosage is 1 gram every 8 to 12 hours
  • Dosage depends on susceptibility of causative organisms
  • Dosage determined by severity of infection and patient's renal function
  • Dosage range for adults is 1 to 6 gm per day
  • Specific dosages for urinary tract infections and severe infections
  • Reduced clearance in acutely ill elderly patients
  • Usual dosage range for children aged over two months

Administration

  • Administered intravenously or by deep IM injection
  • Reconstituted with supplied Sterile Water for Injection

Contraindications

  • Hypersensitivity to Ceftazidime or cephalosporin group antibiotics

Side Effects

  • Local reactions following IV injection
  • Allergic and gastrointestinal reactions
  • Hypersensitivity reactions like pruritus, rash, and fever
  • Gastrointestinal symptoms like diarrhea, nausea, and vomiting
  • Central nervous system reactions like headache and dizziness

Pregnancy & Lactation

  • No adequate and well-controlled studies in pregnant women
  • Excretion in human milk in low concentrations
  • Safety in nursing infants not established

Precautions & Warnings

  • Dosage reduction in patients with renal insufficiency
  • Prescribed with caution in individuals with history of gastrointestinal disease

Use in Special Populations

  • Dosage reduction in patients with impaired renal function
  • Use in peritoneal dialysis and continuous ambulatory peritoneal dialysis (CAPD)
  • No adjustment in dosage required for patients with hepatic dysfunction

Overdose Effects

  • Reactions including seizure activity and coma
  • Patients should be given supportive treatment

Therapeutic Class

  • Third generation Cephalosporins

Reconstitution

  • Specific amounts of Sterile Water for Injection for reconstitution

Storage Conditions

  • Store below 25°C, protected from light and moisture
  • Reconstituted solutions are stable for up to 24 hours if stored between 2°C-8°C

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