Amicard Plus 5 mg+50 mg (Tablet)
Unit Price: ৳ 8.00 (5 x 10: ৳ 400.00)
Strip Price: ৳ 80.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Amlodipine besilate atenolol |
| Company | Aexim pharmaceuticals ltd |
Indications
- Essential hypertension
- Angina pectoris & hypertension as co-existing diseases
- Post Myocardial Infarction (MI) patients
- Refractory angina pectoris
Pharmacology
- Fixed-dose combination of Amlodipine and Atenolol
- Amlodipine: dihydropyridine calcium antagonist
- Amlodipine: peripheral vasodilator
- Amlodipine: reduces peripheral vascular resistance and blood pressure
- Atenolol: cardioselective beta-blocker
- Atenolol: reduces blood pressure by lowering cardiac output
Dosage & Administration
- Recommended dosage: Amlodipine and Atenolol 5/25 mg tablet once daily
- Dosage may be increased as advised by physicians
- Dosage should be individualized
Interaction
- Disopyramide: Atenolol reduces clearance by 20%, producing additive negative inotropic effects
- Ampicillin: reduces Atenolol levels at doses of 1 gm and above
- Oral antidiabetics and insulin: Beta-blockers may decrease tissue sensitivity to insulin and inhibit insulin secretion
Contraindications
- Hypersensitivity to either component
- Sinus bradycardia
- Second and higher degrees of heart block
- Cardiogenic shock
- Hypotension
- Congestive heart failure
- Poor left ventricular function
Side Effects
- Well tolerated
- Side effects include fatigue, headache, edema, nausea, drowsiness, anxiety, depression
Pregnancy & Lactation
- Use during pregnancy if benefit outweighs potential fetal risk
- Not recommended for nursing mothers
Precautions & Warnings
- Bronchospasm: use with caution in patients with airway obstruction
- Renal impairment: caution if creatinine clearance is less than 30 ml/min
- Hepatic impairment: caution in severe liver damage patients
- Drug withdrawal: discontinuation should be gradual
Overdose Effects
- Hypotension
- Congestive cardiac failure
- Unabsorbed drugs may be removed by gastric lavage or administration of activated charcoal
Therapeutic Class
- Combined antihypertensive preparations
Storage Conditions
- Keep below 30°C
- Away from light & moisture
- Keep out of the reach of children