Trum 3 250 mg/vial (IM/IV Injection)

250 mg vial: ৳ 70.25

Medicine Details

Category Details
Generic Ceftazidime pentahydrate
Company Drug international ltd
Also available as
Trum 3 500 mg injection Trum 3 1 gm injection

Title

  • Trum 3 Injection

Categories

  • Antibiotics
  • Cephalosporins
  • Medication
  • Pharmaceuticals
  • Clinical Treatment

Description

  • Broad-spectrum antibiotic
  • Parenteral administration
  • Bactericidal action
  • Cell-wall synthesis inhibition
  • Gram-negative organism susceptibility
  • Resistance to gentamicin and aminoglycosides
  • Activity against gram-positive organisms
  • Beta-lactamase stability
  • Contraindicated in hypersensitivity
  • Common side effects: local reactions, allergic reactions, gastrointestinal reactions
  • Hypersensitivity reactions: pruritus, rash, fever
  • Rare hypersensitivity reactions: angioedema, anaphylaxis
  • Gastrointestinal symptoms: diarrhea, nausea, vomiting, abdominal pain
  • Central nervous system reactions: headache, dizziness, paresthesia
  • Pregnancy caution
  • Lactation caution
  • Renal insufficiency dosage adjustment
  • History of gastrointestinal disease caution
  • Impaired renal function precautions
  • Dosage adjustment in renal insufficiency
  • Dosage in peritoneal dialysis
  • No dosage adjustment for hepatic dysfunction
  • Overdosage effects: seizure activity, encephalopathy, neuromuscular excitability, coma
  • Third generation cephalosporins
  • Storage temperature conditions
  • Reconstitution guidelines

Indications

  • Lower Respiratory Tract Infections
  • Skin and Skin Structure Infections
  • Urinary Tract Infections
  • Bacterial Septicemia
  • Bone and Joint Infections
  • Gynecologic Infections
  • Intraabdominal Infections
  • Central Nervous System Infections

Pharmacology

  • Inhibition of cell-wall synthesis
  • Broad-spectrum action
  • Gram-negative organism susceptibility
  • Resistance to gentamicin and aminoglycosides
  • Activity against gram-positive organisms
  • Beta-lactamase stability

Dosage

  • Adult dosage: 1 gram every 8 to 12 hours
  • Dosage determined by susceptibility, infection severity, renal function
  • Dosage range for adults: 1 to 6 gm per day
  • Dosage reductions for elderly patients
  • Dosage range for children: 30 to 100 mg/kg/day
  • Dosage for neonates and children up to 2 months: 25 to 60 mg/kg/day

Administration

  • Options: intravenous or deep IM injection
  • Avoid intra-arterial administration
  • Reconstitution with Sterile Water for Injection

Contraindications

  • Hypersensitivity to Ceftazidime or cephalosporins

Side effects

  • Local reactions following IV injection
  • Allergic and gastrointestinal reactions
  • Hypersensitivity reactions: pruritus, rash, fever
  • Rare hypersensitivity reactions: angioedema, anaphylaxis
  • Gastrointestinal symptoms: diarrhea, nausea, vomiting, abdominal pain
  • Central nervous system reactions: headache, dizziness, paresthesia

Pregnancy lactation

  • Pregnancy: Use only if clearly needed
  • Lactation: Caution due to low excretion in human milk

Precautions warnings

  • Dosage reduction in renal insufficiency
  • Caution in individuals with gastrointestinal disease
  • Caution in impaired renal and hepatic function

Special populations

  • Renal function impairment precautions
  • Dosage guidelines in peritoneal dialysis
  • No dosage adjustment for hepatic dysfunction

Overdose effects

  • Seizure activity
  • Encephalopathy
  • Neuromuscular excitability
  • Coma

Drug classes

  • Third generation Cephalosporins

Reconstitution

  • Guidelines for reconstitution

Storage conditions

  • Temperature conditions for storage
  • Stability of reconstituted solutions

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