Trum 3 500 mg/vial (IM/IV Injection)

500 mg vial: ৳ 120.40

Medicine Details

Category Details
Generic Ceftazidime pentahydrate
Company Drug international ltd
Also available as
Trum 3 250 mg injection Trum 3 1 gm injection

Indications

  • Lower Respiratory Tract Infections
  • Skin and Skin Structure Infections
  • Urinary Tract Infections
  • Bacterial Septicemia
  • Bone and Joint Infections
  • Gynecologic Infections
  • Intraabdominal Infections
  • Central Nervous System Infections

Pharmacology

  • Bactericidal Action
  • Inhibition of Cell-wall Synthesis
  • Broad-spectrum Antibiotic
  • Susceptibility to Gram-negative and gram-positive organisms

Dosage

  • Usual Adult Dosage: 1 gram every 8 to 12 hours
  • Dosage determination based on susceptibility of causative organisms, severity of infection, and patient's renal function
  • Range of dosage for adults: 1 to 6 gm per day
  • Reduced dosage for acutely ill elderly patients, especially those over 80 years of age
  • High doses for fibrocystic adults with pseudomonal lung infections
  • Usual dosage range for children aged over two months: 30 to 100 mg/kg/day

Administration

  • Can be administered intravenously or by deep IM injection
  • Reconstitution required with supplied Sterile Water for Injection

Contraindications

  • Hypersensitivity to Ceftazidime or cephalosporin group of antibiotics

Side Effects

  • Local reactions following IV injection
  • Allergic and gastrointestinal reactions
  • Hypersensitivity reactions: pruritus, rash, fever, angioedema, anaphylaxis
  • Gastrointestinal symptoms: diarrhea, nausea, vomiting, abdominal pain
  • Central nervous system reactions: headache, dizziness, paresthesia

Pregnancy & Lactation

  • No adequate and well-controlled studies in pregnant women
  • Excretion in human milk in low concentrations

Precautions & Warnings

  • Total daily dosage reduction in renal insufficiency patients
  • Prescription caution in individuals with history of gastrointestinal disease

Use in Special Populations

  • Dosage reduction in patients with impaired renal function
  • Incorporation into dialysis fluid in peritoneal dialysis and continuous ambulatory peritoneal dialysis
  • No dosage adjustment required for patients with hepatic dysfunction

Overdose Effects

  • Occurrence in patients with renal failure
  • Reactions including seizure activity, encephalopathy, neuromuscular excitability, and coma
  • Supportive treatment for patients receiving acute overdosage

Therapeutic Class

  • Third generation Cephalosporins

Reconstitution

  • Specific amounts of WFI to be added for intramuscular and intravenous administration

Storage Conditions

  • Store below 25°C, protected from light and moisture
  • Reconstituted solutions stable for up to 24 hours if stored between 2°C-8°C

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