Zidim 250 mg/vial (IM/IV Injection)
250 mg vial: ৳ 70.48
Medicine Details
| Category | Details |
|---|---|
| Generic | Ceftazidime pentahydrate |
| Company | Orion pharma ltd |
| Also available as |
Indications
- Treatment of lower respiratory tract infections
- Treatment of skin and skin structure infections
- Treatment of urinary tract infections
- Treatment of bacterial septicemia
- Treatment of bone and joint infections
- Treatment of gynecologic infections
- Treatment of intraabdominal infections
- Treatment of central nervous system infections
Pharmacology
- Semisynthetic
- Broad-spectrum
- Bactericidal action
- Inhibition of enzymes responsible for cell-wall synthesis
- Susceptible to a wide range of gram-negative organisms
- Active against gram-positive organisms
- Highly stable to most clinically important beta-lactamases
Dosage
- Usual adult dosage: 1 gram every 8-12 hours
- Dosage determined by susceptibility of causative organisms
- Usable by parenteral route
- Usual dosage range for adults: 1 to 6 gm per day
- Different dosage for urinary tract and severe infections
- Dosage for elderly patients
- Dosage for infants and children
Administration
- Can be given intravenously or by deep IM injection
- Avoid intra-arterial administration
- Reconstitute with Sterile Water for Injection for IV/IM administration
Contraindications
- Contraindicated in patients hypersensitive to Ceftazidime or cephalosporin antibiotics
Side Effects
- Local reactions following IV injection
- Allergic and gastrointestinal reactions
- Hypersensitivity reactions like pruritus, rash, and fever
- Gastrointestinal symptoms like diarrhea, nausea, vomiting, and abdominal pain
- Central nervous system reactions like headache, dizziness, and paresthesia
Pregnancy & Lactation
- No adequate and well-controlled studies in pregnant women
- Excreted in low concentrations in human milk
Precautions & Warnings
- Reduce dosage for patients with renal insufficiency
- Prescribe with caution for individuals with a history of gastrointestinal disease
Use in Special Populations
- Adjust dosage for patients with impaired renal function
- Usable in peritoneal dialysis and continuous ambulatory peritoneal dialysis (CAPD)
- No adjustment in dosage for patients with hepatic dysfunction
Overdose Effects
- Overdosage reactions include seizure activity, encephalopathy, and coma
- Patients should be observed and given supportive treatment
Therapeutic Class
- Third generation Cephalosporins
Reconstitution
- Amount of WFI to be added for IM and IV administration
Storage Conditions
- Store below 25°C
- Protect from light and moisture
- Reconstituted solutions are stable for up to 24 hours if stored between 2°C-8°C