Tazimax 1 gm/vial (IM/IV Injection)

1 gm vial: ৳ 240.00

Medicine Details

Category Details
Generic Ceftazidime pentahydrate
Company Eskayef pharmaceuticals ltd
Also available as
Tazimax 250 mg injection

Title

Tazimax Injection

Categories

  • Medicine
  • Antibiotics
  • Pharmaceuticals

Description

Tazimax Injection is indicated for the treatment of patients with infections caused by susceptible strains of various bacteria. Ceftazidime, the active ingredient, is a broad-spectrum antibiotic with bactericidal action. It is administered intravenously or intramuscularly and is contraindicated in patients with known hypersensitivity to cephalosporin antibiotics. The drug has potential side effects including local reactions, allergic reactions, gastrointestinal symptoms, and central nervous system reactions. It should be used with caution in patients with renal insufficiency and a reduced dosage is recommended in such cases. Tazimax Injection belongs to the therapeutic class of third generation Cephalosporins.

Indications

  • Lower Respiratory Tract Infections
  • Pneumonia
  • Skin and Skin Structure Infections
  • Urinary Tract Infections
  • Bacterial Septicemia
  • Bone and Joint Infections
  • Gynecologic Infections
  • Intraabdominal Infections
  • Central Nervous System Infections

Pharmacology

Ceftazidime is a semisynthetic, broad-spectrum, beta-lactam antibiotic with bactericidal action. It inhibits enzymes responsible for cell-wall synthesis and is effective against a wide range of gram-negative organisms, including strains resistant to gentamicin and other aminoglycosides. It is also active against some gram-positive organisms and stable to most clinically important beta-lactamases.

Dosage

  • Usual Adult Dosage:
    • 1 gram administered intravenously or intramuscularly every 8 to 12 hours
  • Dosage Range for Adults: 1 to 6 gm per day 8 or 12 hourly (IM/IV) in the majority of infections
  • Elderly Dosage: Daily dosage should not normally exceed 3 gm
  • Infants and Children Dosage: 30 to 100 mg/kg/day for children aged over two months. Neonates and Children up to 2 months of age: 25 to 60 mg/kg/day

Administration

  • Intravenous
  • Deep Intramuscular injection

Contraindications

  • Hypersensitivity to Ceftazidime or the cephalosporin group of antibiotics

Side Effects

  • Common Side Effects:
    • Local reactions following IV injection
    • Allergic reactions
    • Gastrointestinal symptoms
    • Central nervous system reactions
  • Hypersensitivity Reactions:
    • Pruritus
    • Rash
    • Fever
    • Angioedema
    • Anaphylaxis

Pregnancy & Lactation

  • Pregnancy: Should be used during pregnancy only if clearly needed
  • Lactation: Excreted in human milk in low concentrations. Decision should be made whether to discontinue nursing or discontinue the drug, considering the importance of the drug to the mother.

Precautions & Warnings

  • Total daily dosage should be reduced in patients with renal insufficiency
  • Prescribed with caution in individuals with a history of gastrointestinal disease

Use in Special Populations

  • Impaired Renal Function: Dosage should be reduced in patients with impaired renal function
  • Impaired Hepatic Function: No adjustment in dosage is required for patients with hepatic dysfunction

Overdose Effects

  • Seizure activity
  • Encephalopathy
  • Asterixis
  • Neuromuscular excitability
  • Coma

Therapeutic Class

Third generation Cephalosporins

Reconstitution

Requires reconstitution with Sterile Water for Injection

Storage Conditions

  • Store below 25°C
  • Protected from light and moisture
  • Reconstituted solutions are stable for up to 24 hours if stored between 2°C-8°C

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