Aciphin 250 mg/vial (IM Injection)

250 mg vial: ৳ 100.30

Medicine Details

Indications

  • Lower respiratory tract infections
  • Acute Bacterial Otitis Media
  • Skin and skin structure infections
  • Urinary tract infections
  • Gonorrhea
  • Bacterial Septicemia
  • Bone and joint infections
  • Meningitis
  • Prevention of postoperative infections
  • Perioperative prophylaxis of infections associated with surgery

Pharmacology

Ceftriaxone is a 3rd generation broad-spectrum parenteral cephalosporin antibiotic with potent bactericidal activity against a wide range of Gram-positive and Gram-negative organisms. It kills bacteria by interfering with the synthesis of the bacterial cell wall, and has a long plasma elimination half-life of about 6 to 9 hours.

Dosage

  • Adult: 1 to 2 gm by intravenous or intramuscular administration once a day (or in equally divided doses twice a day)
  • Infants and Children: 50 to 75 mg/kg intravenous or intramuscular administration once a day (or in equally divided doses twice a day)

Administration

  • Intramuscular Injection: 250 mg or 500 mg Ceftriaxone should be dissolved in Lidocaine HCI 1% injection
  • Intravenous Injection: 250 mg or 500 mg Ceftriaxone should be dissolved in Water for injection

Interaction

No drug interactions reported.

Contraindications

Should not be given to patients with a history of hypersensitivity to cephalosporin antibiotics.

Side Effects

  • Gastro-intestinal effects
  • Cutaneous reactions
  • Hematologic reactions
  • Hepatic reactions
  • CNS reactions
  • Local phlebitis

Pregnancy & Lactation

  • Safety in human pregnancy not established
  • Low concentrations excreted in human milk

Precautions & Warnings

  • Anaphylactic shock
  • Shadows suggesting sludge in gallbladder
  • Blood picture check during prolonged treatment

Use in Special Populations

Must not be given to neonates if premature and newborn (up to 28 days of age)

Overdose Effects

No specific antidote, symptomatic treatment advised

Therapeutic Class

Third generation Cephalosporins

Storage Conditions

Store in a cool, dry place below 30° C, away from light & moisture

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