Aciphin 500 mg/vial (IM Injection)

500 mg vial: ৳ 130.39

Medicine Details

Category Details
Generic Ceftriaxone sodium
Company Aci limited
Also available as
Aciphin 250 mg injection Aciphin 1 gm injection Aciphin 250 mg injection Aciphin 500 mg injection Aciphin 1 gm injection Aciphin 2 gm injection

Indications

  • Lower respiratory tract infections
  • Acute Bacterial Otitis Media
  • Skin and skin structure infections
  • Urinary tract infections
  • Gonorrhea
  • Bacterial Septicemia
  • Bone and joint infections
  • Meningitis
  • Prevention of postoperative infections
  • Perioperative prophylaxis of infections associated with surgery

Pharmacology

Ceftriaxone is a 3rd generation broad-spectrum parenteral cephalosporin antibiotic. It has potent bactericidal activity against a wide range of Gram-positive and Gram-negative organisms. Ceftriaxone has a high degree of stability in the presence of beta lactamases.

Dosage

  • Adult: 1 to 2 gm by intravenous or intramuscular administration once a day
  • Uncomplicated gonococcal infections: 250 mg IM as a single dose
  • Surgical prophylaxis: 1 g IV as a single dose 30 to 120 minutes before surgery
  • Infants and Children: 50 to 75 mg/kg intravenous or intramuscular administration once a day

Administration

  • For Intramuscular Injection: 250 mg or 500 mg Ceftriaxone should be dissolved in Lidocaine HCI 1% injection
  • For Intravenous Injection: 250 mg or 500 mg Ceftriaxone should be dissolved in Water for injection
  • The injection should be administered over 2-4 minutes, by Intramuscular or Intravenous injection or by tubing infusion over a period of 30 minutes

Interaction

No drug interactions have been reported.

Contraindications

Ceftriaxone should not be given to patients with a history of hypersensitivity to cephalosporin antibiotics.

Side Effects

  • Gastro-intestinal effects including diarrhea, nausea and vomiting
  • Cutaneous reactions including rash, pruritus, urticaria
  • Hematologic reactions including eosinophilia, thrombocytopenia, leucopenia
  • Hepatic reactions including elevations of SGOT or SGPT, bilirubinemia
  • CNS reactions including nervousness, confusion, sleep disturbances

Pregnancy & Lactation

Its safety in human pregnancy has not been established. Caution should be exercised when Ceftriaxone is administered to a lactating mother.

Precautions & Warnings

  • Anaphylactic shock cannot be ruled out
  • Shadows suggesting sludge have been detected by sonograms of the gallbladder
  • During prolonged treatment the blood picture should be checked at regular intervals

Use in Special Populations

Aciphin must not be given to neonates if the neonate is premature and newborn (up to 28 days of age)

Overdose Effects

There is no specific antidote. Treatment of overdosage should be symptomatic.

Therapeutic Class

Third generation Cephalosporins

Storage Conditions

Vial store in a cool, dry place (below 30°C), away from light & moisture. Keep out of the reach of children.

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