Aciphin 1 gm/vial (IV Injection)

1 gm vial: ৳ 191.29

Medicine Details

Category Details
Generic Ceftriaxone sodium
Company Aci limited
Also available as
Aciphin 250 mg injection Aciphin 500 mg injection Aciphin 1 gm injection Aciphin 250 mg injection Aciphin 500 mg injection Aciphin 2 gm injection

Indications

  • Lower respiratory tract infections
  • Acute Bacterial Otitis Media
  • Skin and skin structure infections
  • Urinary tract infections
  • Gonorrhea
  • Bacterial Septicemia
  • Bone and joint infections
  • Meningitis
  • Prevention of postoperative infections
  • Perioperative prophylaxis of infections associated with surgery

Pharmacology

  • Broad-spectrum parenteral cephalosporin antibiotic
  • Bactericidal activity against Gram-positive and Gram-negative organisms
  • Interference with bacterial cell wall synthesis
  • High degree of stability in the presence of beta lactamases
  • Long plasma elimination half-life of 6 to 9 hours
  • Non-metabolized in the body
  • Excretion of 40-65% unchanged in urine
  • Highly protein bound (95%)

Dosage

  • Usual dose for adults: 1 to 2 gm by intravenous or intramuscular administration once a day
  • Maximum dose for adults: 4 gm/day
  • Usual dose for infants and children: 50 to 75 mg/kg intravenous or intramuscular administration once a day
  • Maximum dose for infants and children: 2 gm/day
  • Duration of therapy: 4 to 14 days; longer therapy for complicated infections

Administration

  • Preparation of Solutions for Intramuscular / Intravenous Injections
  • Intramuscular injection with Lidocaine HCI 1%
  • Intravenous injection with Water for injection
  • Injection administered over 2-4 minutes or tubing infusion over 30 minutes
  • Recommendation for patient tolerance test before treatment
  • Potency maintenance for at least 6 hours at room temperature or 24 hours at 5°C

Interaction

  • No reported drug interactions

Contraindications

  • Not for patients with history of hypersensitivity to cephalosporin antibiotics

Side Effects

  • Gastro-intestinal effects including diarrhea, nausea, vomiting, stomatitis, and glossitis
  • Cutaneous reactions including rash, pruritus, urticaria, edema, and erythema multiforme
  • Hematologic reactions including eosinophilia, thrombocytopenia, leucopenia, anemia, and neutropenia
  • Hepatic reactions including elevations of SGOT or SGPT, bilirubinemia
  • CNS reactions including nervousness, confusion, sleep disturbances, headache, hyperactivity, convulsion, hypertonia, and dizziness
  • Rare occurrence of local phlebitis following intravenous administration

Pregnancy & Lactation

  • Safety in human pregnancy not established
  • Caution in lactating mothers due to low concentrations excreted in human milk

Precautions & Warnings

  • Anaphylactic shock risk
  • Occasional detection of sludge shadows in the gallbladder, reversible on discontinuation
  • Regular blood picture check during prolonged treatment

Use in Special Populations

  • Not for newborns up to 28 days of age

Overdose Effects

  • No specific antidote; symptomatic treatment recommended

Therapeutic Class

  • Third generation Cephalosporins

Storage Conditions

  • Store in a cool, dry place below 30° C, away from light and moisture
  • Keep out of the reach of children

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