Aciphin 2 gm/vial (IV Injection)
Medicine Details
| Category | Details |
|---|---|
| Generic | Ceftriaxone sodium |
| Company | Aci limited |
| Also available as |
Indications
- Lower respiratory tract infections
- Acute Bacterial Otitis Media
- Skin and skin structure infections
- Urinary tract infections
- Gonorrhea
- Bacterial Septicemia
- Bone and joint infections
- Meningitis
- Prevention of postoperative infections
- Perioperative prophylaxis of infections associated with surgery
Pharmacology
Ceftriaxone is a 3rd generation broad-spectrum parenteral cephalosporin antibiotic with potent bactericidal activity against a wide range of Gram-positive and Gram-negative organisms. It kills bacteria by interfering with the synthesis of the bacterial cell wall. Ceftriaxone has a high degree of stability in the presence of beta lactamases and a relatively long plasma elimination half-life of about 6 to 9 hours. It is not metabolized in the body and is highly protein bound (95%).
Dosage
- Adult:
- 1 to 2 gm by intravenous or intramuscular administration once a day (or in equally divided doses twice a day)
- Maximum dose: 4 gm/day
- Infants and Children (01 month or older):
- 50 to 75 mg/kg intravenous or intramuscular administration once a day (or in equally divided doses twice a day)
- Maximum dose: 2 gm/day
Administration
- Preparation of Solutions for Intramuscular / Intravenous Injections using specific quantities of Ceftriaxone and Lidocaine HCI or Water for injection. The injection should be administered over 2-4 minutes or by tubing infusion over a period of 30 minutes at specific concentration levels.
- Patient tolerance test should be checked by administration of a test dose before starting treatment through Ceftriaxone injection.
Interaction
No drug interactions have been reported.
Contraindications
Ceftriaxone should not be given to patients with a history of hypersensitivity to cephalosporin antibiotics.
Side Effects
- Gastro-intestinal effects including diarrhea, nausea and vomiting, stomatitis and glossitis
- Cutaneous reactions including rash, pruritus, urticaria, edema and erythema multiforme
- Hematologic reactions including eosinophilia, thrombocytopenia, leucopenia, anemia and neutropenia
- Hepatic reactions including elevations of SGOT or SGPT, bilirubinemia
- CNS reactions including nervousness, confusion, sleep disturbances, headache, hyperactivity, convulsion, hypertonia and dizziness
- Local phlebitis occurs rarely following intravenous administration but can be minimized by slow injections over 2-4 minutes.
Pregnancy & Lactation
Its safety in human pregnancy has not been established. Therefore, it should not be used in pregnancy unless absolutely indicated. Caution should be exercised when Ceftriaxone is administered to a lactating mother.
Precautions & Warnings
- Anaphylactic shock cannot be ruled out even if a thorough patient history is taken
- Anaphylactic shock requires immediate countermeasures such as intravenous epinephrine followed by a glucocorticoid
- Shadows suggesting sludge have been detected by sonograms of the gallbladder; conservative, nonsurgical management is recommended
- Blood picture should be checked at regular intervals during prolonged treatment
Use in Special Populations
Aciphin must not be given to neonates if the neonate is premature and newborn (up to 28 days of age).
Overdose Effects
There is no specific antidote. Treatment of overdosage should be symptomatic.
Therapeutic Class
Third generation Cephalosporins
Storage Conditions
Vial store in a cool, dry place (below 30° C), away from light & moisture. Keep out of the reach of children.