Aciphin 2 gm/vial (IV Injection)

2 gm vial: ৳ 302.04

Medicine Details

Category	Details
Generic	Ceftriaxone sodium
Company	Aci limited
Also available as	Aciphin 250 mg injection Aciphin 500 mg injection Aciphin 1 gm injection Aciphin 250 mg injection Aciphin 500 mg injection Aciphin 1 gm injection

Indications

Lower respiratory tract infections
Acute Bacterial Otitis Media
Skin and skin structure infections
Urinary tract infections
Gonorrhea
Bacterial Septicemia
Bone and joint infections
Meningitis
Prevention of postoperative infections
Perioperative prophylaxis of infections associated with surgery

Pharmacology

Ceftriaxone is a 3rd generation broad-spectrum parenteral cephalosporin antibiotic with potent bactericidal activity against a wide range of Gram-positive and Gram-negative organisms. It kills bacteria by interfering with the synthesis of the bacterial cell wall. Ceftriaxone has a high degree of stability in the presence of beta lactamases and a relatively long plasma elimination half-life of about 6 to 9 hours. It is not metabolized in the body and is highly protein bound (95%).

Dosage

Adult:
- 1 to 2 gm by intravenous or intramuscular administration once a day (or in equally divided doses twice a day)
- Maximum dose: 4 gm/day
Infants and Children (01 month or older):
- 50 to 75 mg/kg intravenous or intramuscular administration once a day (or in equally divided doses twice a day)
- Maximum dose: 2 gm/day

Administration

Preparation of Solutions for Intramuscular / Intravenous Injections using specific quantities of Ceftriaxone and Lidocaine HCI or Water for injection. The injection should be administered over 2-4 minutes or by tubing infusion over a period of 30 minutes at specific concentration levels.
Patient tolerance test should be checked by administration of a test dose before starting treatment through Ceftriaxone injection.

Interaction

No drug interactions have been reported.

Contraindications

Ceftriaxone should not be given to patients with a history of hypersensitivity to cephalosporin antibiotics.

Side Effects

Gastro-intestinal effects including diarrhea, nausea and vomiting, stomatitis and glossitis
Cutaneous reactions including rash, pruritus, urticaria, edema and erythema multiforme
Hematologic reactions including eosinophilia, thrombocytopenia, leucopenia, anemia and neutropenia
Hepatic reactions including elevations of SGOT or SGPT, bilirubinemia
CNS reactions including nervousness, confusion, sleep disturbances, headache, hyperactivity, convulsion, hypertonia and dizziness
Local phlebitis occurs rarely following intravenous administration but can be minimized by slow injections over 2-4 minutes.

Pregnancy & Lactation

Its safety in human pregnancy has not been established. Therefore, it should not be used in pregnancy unless absolutely indicated. Caution should be exercised when Ceftriaxone is administered to a lactating mother.

Precautions & Warnings

Anaphylactic shock cannot be ruled out even if a thorough patient history is taken
Anaphylactic shock requires immediate countermeasures such as intravenous epinephrine followed by a glucocorticoid
Shadows suggesting sludge have been detected by sonograms of the gallbladder; conservative, nonsurgical management is recommended
Blood picture should be checked at regular intervals during prolonged treatment

Use in Special Populations

Aciphin must not be given to neonates if the neonate is premature and newborn (up to 28 days of age).

Overdose Effects

There is no specific antidote. Treatment of overdosage should be symptomatic.

Therapeutic Class

Third generation Cephalosporins

Storage Conditions

Vial store in a cool, dry place (below 30° C), away from light & moisture. Keep out of the reach of children.