Arixon 250 mg/vial (IM Injection)

250 mg vial: ৳ 100.00

Medicine Details

Category Details
Generic Ceftriaxone sodium
Company Beximco pharmaceuticals ltd
Also available as
Arixon 500 mg injection Arixon 1 gm injection Arixon 250 mg injection Arixon 500 mg injection Arixon 1 gm injection Arixon 2 gm injection

Indications

  • Lower respiratory tract infections
  • Acute Bacterial Otitis Media
  • Skin and skin structure infections
  • Urinary tract infections
  • Gonorrhea
  • Bacterial Septicemia
  • Bone and joint infections
  • Meningitis
  • Prevention of postoperative infections
  • Perioperative prophylaxis of infections associated with surgery

Pharmacology

Ceftriaxone is a 3rd generation broad-spectrum parenteral cephalosporin antibiotic. It has potent bactericidal activity against a wide range of Gram-positive and Gram-negative organisms.

Dosage

  • Adult:
    • 1 to 2 gm by intravenous or intramuscular administration once a day
    • 1 to 2 g IV or IM once a day (or in equally divided doses twice a day); Maximum dose: 4 gm/day
    • 250 mg IM as a single dose for uncomplicated gonococcal infections
    • 1 g IV as a single dose 30 to 120 minutes before surgery
  • Infants and Children (01 month or older):
    • 50 to 75 mg/kg intravenous or intramuscular administration once a day
    • 50 to 75 mg/kg IV or IM once a day (or in equally divided doses twice a day); Maximum dose: 2 gm/day for various infections
    • 100 mg/kg IV or IM in single daily dose for Meningitis; Maximum dose: 4 gm/day
  • Duration of Therapy: Continue for more than 2 days after signs and symptoms of infection have disappeared. Usual duration is 4 to 14 days; in complicated infections, longer therapy may be required.

Administration

  • Intramuscular Injection: 250 mg or 500 mg Ceftriaxone should be dissolved in Lidocaine HCI 1% injection
  • Intravenous Injection: 250 mg or 500 mg Ceftriaxone should be dissolved in Water for injection or 1 g / 2 g Ceftriaxone in appropriate amount of Water for injection
  • Injection Administration: Administered over 2-4 minutes by Intramuscular or Intravenous injection or by tubing infusion over a period of 30 minutes at appropriate concentration

Interaction

No drug interactions reported

Contraindications

Ceftriaxone should not be given to patients with a history of hypersensitivity to cephalosporin antibiotics.

Side Effects

  • Gastro-intestinal effects including diarrhea, nausea and vomiting
  • Cutaneous reactions including rash, pruritus, urticaria, edema and erythema multiforme
  • Hematologic reactions including eosinophilia, thrombocytopenia, leucopenia, anemia and neutropenia
  • Hepatic reactions including elevations of SGOT or SGPT, bilirubinemia
  • CNS reactions including nervousness, confusion, sleep disturbances, headache, convulsion, hypertonia and dizziness
  • Local phlebitis following intravenous administration

Pregnancy & Lactation

Safety in human pregnancy not established. Caution advised during lactation.

Precautions & Warnings

  • Anaphylactic shock may occur
  • Check blood picture during prolonged treatment
  • Conservative management advised for gallbladder concerns
  • Special caution for neonates if premature or newborn

Overdose Effects

No specific antidote; symptomatic treatment

Therapeutic Class

Third generation Cephalosporins

Storage Conditions

Store in a cool, dry place (below 30° C), away from light & moisture. Keep out of the reach of children.

Related Brands