Arixon 250 mg/vial (IV Injection)
250 mg vial: ৳ 100.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Ceftriaxone sodium |
| Company | Beximco pharmaceuticals ltd |
| Also available as |
Indications
- Lower respiratory tract infections
- Acute Bacterial Otitis Media
- Skin and skin structure infections
- Urinary tract infections
- Gonorrhea
- Bacterial Septicemia
- Bone and joint infections
- Meningitis
- Prevention of postoperative infections
- Perioperative prophylaxis of infections associated with surgery
Pharmacology
- Broad-spectrum parenteral cephalosporin antibiotic
- Bactericidal activity against a wide range of Gram-positive and Gram-negative organisms
- Interfering with the synthesis of the bacterial cell wall
- High degree of stability in the presence of beta lactamases
- Relatively long plasma elimination half-life of about 6 to 9 hours
Dosage
- Usual dose for adults is 1 to 2 gm by intravenous or intramuscular administration once a day
- Maximum dose is 4 gm/day for certain infections
- Usual dose for infants and children is 50 to 75 mg/kg intravenous or intramuscular administration once a day
- Maximum dose for children is 2 gm/day for certain infections
- Duration of therapy is usually 4 to 14 days
Administration
- Preparation of Solutions for Intramuscular / Intravenous Injections
- Should be dissolved in Lidocaine HCI 1% injection for intramuscular injection
- Should be dissolved in Water for injection for intravenous injection
- Injection should be administered over 2-4 minutes
- Patient tolerance test should be checked by administration of a test dose
Interaction
- No drug interactions reported
Contraindications
- Patients with a history of hypersensitivity to cephalosporin antibiotics
Side Effects
- Gastro-intestinal effects including diarrhea, nausea and vomiting
- Cutaneous reactions including rash, pruritus, urticaria
- Hematologic reactions including eosinophilia, thrombocytopenia, leucopenia
- Hepatic reactions including elevations of SGOT or SGPT, bilirubinemia
- CNS reactions including nervousness, confusion, sleep disturbances
Pregnancy & Lactation
- Not established safety in human pregnancy
- Caution should be exercised when administered to a lactating mother
Precautions & Warnings
- Anaphylactic shock cannot be ruled out
- Shadows suggesting sludge have been detected by sonograms of the gallbladder
- Blood picture should be checked at regular intervals during prolonged treatment
Use in Special Populations
- Must not be given to neonates if premature and newborn
Overdose Effects
- No specific antidote. Treatment should be symptomatic
Therapeutic Class
- Third generation Cephalosporins
Storage Conditions
- Store in a cool, dry place (below 30°C), away from light & moisture