Arixon 500 mg/vial (IV Injection)

500 mg vial: ৳ 130.00

Medicine Details

Category	Details
Generic	Ceftriaxone sodium
Company	Beximco pharmaceuticals ltd
Also available as	Arixon 250 mg injection Arixon 500 mg injection Arixon 1 gm injection Arixon 250 mg injection Arixon 1 gm injection Arixon 2 gm injection

Indications

Lower respiratory tract infections
Acute Bacterial Otitis Media
Skin and skin structure infections
Urinary tract infections
Gonorrhea
Bacterial Septicemia
Bone and joint infections
Meningitis
Prevention of postoperative infections
Perioperative prophylaxis of infections associated with surgery

Pharmacology

Ceftriaxone is a 3rd generation broad-spectrum parenteral cephalosporin antibiotic. It has potent bactericidal activity against a wide range of Gram-positive and Gram-negative organisms. It has a high degree of stability in the presence of beta lactamases. It has a relatively long plasma elimination half-life of about 6 to 9 hours, making single or once-daily dosage appropriate for most patients. Ceftriaxone is not metabolized in the body. About 40-65% of a dose of Ceftriaxone is excreted unchanged in the urine, and the remainder is excreted in the bile and ultimately found in the feces as unchanged drug and microbiologically inactive compound. The drug is highly protein bound (95%).

Dosage

Adult:
- 1 to 2 gm by intravenous or intramuscular administration once a day (or in equally divided doses twice a day)
- Maximum dose: 4 gm/day
Infants and Children (01 month or older):
- 50 to 75 mg/kg intravenous or intramuscular administration once a day (or in equally divided doses twice a day)
- Duration of therapy: Continue for more than 2 days after signs and symptoms of infection have disappeared. Usual duration is 4 to 14 days; in complicated infections, longer therapy may be required.

Administration

Injection should be administered over 2-4 minutes, by intramuscular or intravenous injection or by tubing infusion over a period of 30 minutes at concentration between 10 mg/mL and 40 mg/mL.
Patient tolerance test should be checked by administration of a test dose.
Freshly reconstituted solution is recommended. However, it maintains potency for at least 6 hours at room temperature or 24 hours at 5°C.

Interaction

No drug interactions have been reported.

Contraindications

Ceftriaxone should not be given to patients with a history of hypersensitivity to cephalosporin antibiotics.

Side Effects

Gastro-intestinal effects including diarrhea, nausea and vomiting, stomatitis and glossitis
Cutaneous reactions including rash, pruritus, urticaria, edema and erythema multiforme
Hematologic reactions including eosinophilia, thrombocytopenia, leucopenia, anemia and neutropenia
Hepatic reactions including elevations of SGOT or SGPT, bilirubinemia
CNS reactions including nervousness, confusion, sleep disturbances, headache, hyperactivity, convulsion, hypertonia and dizziness
Local phlebitis occurs rarely following intravenous administration

Pregnancy & Lactation

Its safety in human pregnancy has not been established. Therefore, it should not be used in pregnancy unless absolutely indicated. Low concentrations of Ceftriaxone are excreted in human milk. Caution should be exercised when Ceftriaxone is administered to a lactating mother.

Precautions & Warnings

Anaphylactic shock cannot be ruled out even if a thorough patient history is taken
Anaphylactic shock requires immediate countermeasures such as intravenous epinephrine followed by a glucocorticoid
Shadows suggesting sludge have been detected by sonograms of the gallbladder in rare cases
Blood picture should be checked at regular intervals during prolonged treatment

Use in Special Populations

Arixon must not be given to neonates if the neonate is premature and newborn (up to 28 days of age).

Overdose Effects

There is no specific antidote. Treatment of overdosage should be symptomatic.

Therapeutic Class

Third generation Cephalosporins

Storage Conditions

Vial store in a cool, dry place (below 30°C), away from light & moisture. Keep out of the reach of children.