Axon 500 mg/vial (IV Injection)

500 mg vial: ৳ 130.00

Medicine Details

Category Details
Generic Ceftriaxone sodium
Company Aristopharma ltd
Also available as
Axon 250 mg injection Axon 500 mg injection Axon 1 gm injection Axon 250 mg injection Axon 1 gm injection Axon 2 gm injection

Indications

  • Lower respiratory tract infections
  • Acute Bacterial Otitis Media
  • Skin and skin structure infections
  • Urinary tract infections
  • Gonorrhea
  • Bacterial Septicemia
  • Bone and joint infections
  • Meningitis
  • Prevention of postoperative infections
  • Perioperative prophylaxis of infections associated with surgery

Pharmacology

Ceftriaxone is a 3rd generation broad-spectrum parenteral cephalosporin antibiotic with potent bactericidal activity against a wide range of Gram-positive and Gram-negative organisms.

Dosage

  • Adult:
    • 1 to 2 gm by intravenous or intramuscular administration once a day
    • 1 to 2 g IV or IM once a day (or in equally divided doses twice a day) for specific conditions
    • 250 mg IM as a single dose for uncomplicated gonococcal infections
    • 1 g IV as a single dose 30 to 120 minutes before surgery for surgical prophylaxis
  • Infants and Children:
    • 50 to 75 mg/kg intravenous or intramuscular administration once a day (or in equally divided doses twice a day) for specific conditions
  • Duration of therapy: Continue for more than 2 days after signs and symptoms of infection have disappeared. Usual duration is 4 to 14 days; in complicated infections, longer therapy may be required.

Administration

  • Intramuscular Injection:
    • Dissolve 250 mg or 500 mg Ceftriaxone in Lidocaine HCI 1% injection
    • Dose of 1 g Ceftriaxone in 3.5 ml of Lidocaine HCI 1% injection
  • Intravenous Injection:
    • Dissolve 250 mg or 500 mg Ceftriaxone in Water for Injection
    • Dose of 1 g Ceftriaxone in 10 ml of Water for Injection USP
    • Dose of 2 g Ceftriaxone in 20 ml of Water for Injection
  • Administration Time: 2-4 minutes for injection, 30 minutes for tubing infusion at concentration between 10 mg/mL and 40 mg/mL

Interaction

No drug interactions reported

Contraindications

Patients with a history of hypersensitivity to cephalosporin antibiotics

Side Effects

  • Gastro-intestinal effects:
    • Diarrhea
    • Nausea and vomiting
    • Stomatitis
    • Glossitis
  • Cutaneous reactions:
    • Rash
    • Pruritus
    • Urticaria
    • Edema
    • Erythema multiforme
  • Hematologic reactions:
    • Eosinophilia
    • Thrombocytopenia
    • Leucopenia
    • Anemia
    • Neutropenia
  • Hepatic reactions:
    • Elevations of SGOT or SGPT
    • Bilirubinemia
  • CNS reactions:
    • Nervousness
    • Confusion
    • Sleep disturbances
    • Headache
    • Hyperactivity
    • Convulsion
    • Hypertonia
    • Dizziness
  • Local reaction: Rare cases of local phlebitis

Pregnancy & Lactation

Not established in human pregnancy, caution in lactation

Precautions & Warnings

  • Anaphylactic shock precaution
  • Sludge in gallbladder precaution
  • Regular blood picture check during prolonged treatment

Use in Special Populations

Avoid in premature and newborn neonates (up to 28 days of age)

Overdose Effects

No specific antidote. Treatment should be symptomatic.

Therapeutic Class

Third generation Cephalosporins

Storage Conditions

Store in a cool, dry place (below 30° C), away from light & moisture. Keep out of the reach of children.

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