Axon 1 gm/vial (IV Injection)
Medicine Details
| Category | Details |
|---|---|
| Generic | Ceftriaxone sodium |
| Company | Aristopharma ltd |
| Also available as |
Indications
- Lower respiratory tract infections
- Acute Bacterial Otitis Media
- Skin and skin structure infections
- Urinary tract infections
- Gonorrhea
- Bacterial Septicemia
- Bone and joint infections
- Meningitis
- Prevention of postoperative infections
- Perioperative prophylaxis of infections associated with surgery
Pharmacology
Ceftriaxone is a 3rd generation broad-spectrum parenteral cephalosporin antibiotic with potent bactericidal activity against a wide range of Gram-positive and Gram-negative organisms. It has a high degree of stability in the presence of beta lactamases and a long plasma elimination half-life of about 6 to 9 hours.
Dosage
- Adult: 1 to 2 gm by intravenous or intramuscular administration once a day (or in equally divided doses twice a day)
- Infants and Children (01 month or older): 50 to 75 mg/kg intravenous or intramuscular administration once a day (or in equally divided doses twice a day)
- Duration of therapy: Continue for more than 2 days after signs and symptoms of infection have disappeared. Usual duration is 4 to 14 days; in complicated infections, longer therapy may be required.
Administration
- Intramuscular Injection: 250 mg or 500 mg Ceftriaxone should be dissolved in Lidocaine HCI 1% injection
- Intravenous Injection: 250 mg or 500 mg Ceftriaxone should be dissolved in Water for injection or concentrated at a specified concentration for tubing infusion
Interaction
No drug interactions reported
Contraindications
Patients with a history of hypersensitivity to cephalosporin antibiotics
Side Effects
- Gastro-intestinal effects including diarrhea, nausea and vomiting
- Cutaneous reactions including rash, pruritus, urticaria, edema and erythema multiforme
- Hematologic reactions including eosinophilia, thrombocytopenia, leucopenia, anemia and neutropenia
- Hepatic reactions including elevations of SGOT or SGPT, bilirubinemia
- CNS reactions including nervousness, confusion, sleep disturbances, headache, hyperactivity, convulsion, hypertonia and dizziness
- Local phlebitis rare following intravenous administration
Pregnancy & Lactation
Safety in human pregnancy not established. Low concentrations excreted in human milk. Caution when administered to lactating mother.
Precautions & Warnings
- Anaphylactic shock requires immediate countermeasures such as intravenous epinephrine followed by a glucocorticoid
- Shadows suggesting sludge detected by sonograms of the gallbladder, reversible on discontinuation or completion of Axon therapy
- Blood picture should be checked at regular intervals during prolonged treatment
Use in Special Populations
Must not be given to premature and newborn neonates (up to 28 days of age)
Overdose Effects
No specific antidote. Treatment of overdosage should be symptomatic
Therapeutic Class
Third generation Cephalosporins
Storage Conditions
Vial store in a cool, dry place (below 30° C), away from light & moisture. Keep out of the reach of children