Axosin 500 mg/vial (IM Injection)
Medicine Details
| Category | Details |
|---|---|
| Generic | Ceftriaxone sodium |
| Company | Ibn sina pharmaceuticals ltd |
| Also available as |
Indications
- Lower respiratory tract infections
- Acute Bacterial Otitis Media
- Skin and skin structure infections
- Urinary tract infections
- Gonorrhea
- Bacterial Septicemia
- Bone and joint infections
- Meningitis
- Prevention of postoperative infections
- Perioperative prophylaxis of infections associated with surgery
Pharmacology
Ceftriaxone is a 3rd generation broad-spectrum parenteral cephalosporin antibiotic. It has potent bactericidal activity against a wide range of Gram-positive and Gram-negative organisms. Ceftriaxone kills bacteria by interfering with the synthesis of the bacterial cell wall.
Dosage
- Adult: 1 to 2 gm by intravenous or intramuscular administration once a day (or in equally divided doses twice a day)
- Infants and Children (01 month or older): 50 to 75 mg/kg intravenous or intramuscular administration once a day (or in equally divided doses twice a day)
- Duration of therapy: 4 to 14 days; in complicated infections, longer therapy may be required
Administration
- For Intramuscular Injection: 250 mg or 500 mg Ceftriaxone should be dissolved in Lidocaine HCI 1% injection
- For Intravenous Injection: 250 mg or 500 mg Ceftriaxone should be dissolved in Water for injection
- Injection Time: 2-4 minutes for intramuscular or intravenous injection
Interaction
No drug interactions have been reported
Contraindications
Ceftriaxone should not be given to patients with a history of hypersensitivity to cephalosporin antibiotics
Side Effects
- Diarrhea
- Nausea and vomiting
- Rash
- Pruritus
- Eosinophilia
- Thrombocytopenia
- Elevations of SGOT or SGPT
- Local phlebitis following intravenous administration
Pregnancy & Lactation
Its safety in human pregnancy has not been established. Caution should be exercised when Ceftriaxone is administered to a lactating mother
Precautions & Warnings
- Risk of anaphylactic shock
- Shadows suggesting sludge in the gallbladder
- Regular blood picture checks during prolonged treatment
Use in Special Populations
Axosin must not be given to neonates if the neonate is premature and newborn (up to 28 days of age)
Overdose Effects
There is no specific antidote. Treatment of overdosage should be symptomatic
Therapeutic Class
Third generation Cephalosporins
Storage Conditions
Vial store in a cool, dry place (below 30°C), away from light & moisture