Axosin 1 gm/vial (IV Injection)
1 gm vial: ৳ 180.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Ceftriaxone sodium |
| Company | Ibn sina pharmaceuticals ltd |
| Also available as |
Indications
- Lower respiratory tract infections
- Acute Bacterial Otitis Media
- Skin and skin structure infections
- Urinary tract infections
- Gonorrhea
- Bacterial Septicemia
- Bone and joint infections
- Meningitis
- Prevention of postoperative infections
- Perioperative prophylaxis of infections associated with surgery
Pharmacology
- Broad-spectrum parenteral cephalosporin antibiotic
- Potent bactericidal activity
- Interferes with the synthesis of bacterial cell wall
- High degree of stability in the presence of beta lactamases
- Long plasma elimination half-life of 6 to 9 hours
- Not metabolized in the body
- 40-65% excreted unchanged in the urine
- Highly protein bound (95%)
Dosage
- 1-2 gm for adults by intravenous or intramuscular administration
- 250 mg for uncomplicated gonococcal infections
- 1 g for surgical prophylaxis
- 50-75 mg/kg for infants and children
- Continue for more than 2 days after signs and symptoms of infection have disappeared
- Usual duration is 4 to 14 days
Administration
- Intramuscular or intravenous injection
- Administration over 2-4 minutes
- Various concentrations for reconstituted solution
- Patient tolerance test recommended before treatment
- Potency maintained for at least 6 hours at room temperature or 24 hours at 5°C
Interaction
No drug interactions reported
Contraindications
- Hypersensitivity to cephalosporin antibiotics
Side Effects
- Gastro-intestinal effects
- Cutaneous reactions
- Hematologic reactions
- Hepatic reactions
- CNS reactions
- Local phlebitis following intravenous administration
Pregnancy & Lactation
- Safety not established in human pregnancy
- Caution in lactating mothers due to excretion in human milk
Precautions & Warnings
- Potential for anaphylactic shock
- Monitoring blood picture during prolonged treatment
Use in Special Populations
- Avoid in premature and newborn neonates
Overdose Effects
No specific antidote. Treatment should be symptomatic
Therapeutic Class
Third generation Cephalosporins
Storage Conditions
Store in a cool, dry place (below 30°C), away from light & moisture. Keep out of the reach of children