Cefixon 2 gm/vial (IV Injection)
Medicine Details
| Category | Details |
|---|---|
| Generic | Ceftriaxone sodium |
| Company | Techno drugs ltd |
| Also available as |
Indications
- Lower respiratory tract infections
- Acute Bacterial Otitis Media
- Skin and skin structure infections
- Urinary tract infections
- Gonorrhea
- Bacterial Septicemia
- Bone and joint infections
- Meningitis
- Prevention of postoperative infections
- Perioperative prophylaxis of infections associated with surgery
Pharmacology
Ceftriaxone is a 3rd generation broad-spectrum parenteral cephalosporin antibiotic with potent bactericidal activity against a wide range of Gram-positive and Gram-negative organisms. It kills bacteria by interfering with the synthesis of the bacterial cell wall. Ceftriaxone has a high degree of stability in the presence of beta lactamases and a relatively long plasma elimination half-life of about 6 to 9 hours. It is not metabolized in the body and is highly protein bound (95%).
Dosage
- Adult:
- 1 to 2 gm by intravenous or intramuscular administration once a day (or in equally divided doses twice a day)
- Maximum dose: 4 gm/day for certain infections
- Infants and Children (01 month or older):
- 50 to 75 mg/kg intravenous or intramuscular administration once a day (or in equally divided doses twice a day)
- Maximum dose: 2 gm/day for certain infections
- Duration of therapy: Continue for more than 2 days after signs and symptoms of infection have disappeared. Usual duration is 4 to 14 days; in complicated infections, longer therapy may be required.
Administration
- Preparation of Solutions for Intramuscular / Intravenous Injections
- Dissolution guidelines for different doses
- Recommended injection administration time and concentration
- Checking patient tolerance before starting treatment
- Stability of reconstituted solution
Interaction
No drug interactions reported
Contraindications
Patients with a history of hypersensitivity to cephalosporin antibiotics
Side Effects
- Gastro-intestinal effects
- Cutaneous reactions
- Hematologic reactions
- Hepatic reactions
- CNS reactions
- Local phlebitis
Pregnancy & Lactation
Safety in human pregnancy not established. Caution advised during lactation.
Precautions & Warnings
- Risk of anaphylactic shock
- Potential gallbladder conditions
- Blood picture checking during prolonged treatment
Use in Special Populations
Avoid in neonates if premature and newborn (up to 28 days of age)
Overdose Effects
No specific antidote. Symptomatic treatment recommended.
Therapeutic Class
Third generation Cephalosporins
Storage Conditions
Vial store in a cool, dry place (below 30° C), away from light & moisture. Keep out of the reach of children.