Ceftizone 250 mg/vial (IM Injection)
250 mg vial: ৳ 100.38
Medicine Details
| Category | Details |
|---|---|
| Generic | Ceftriaxone sodium |
| Company | Renata limited |
| Also available as |
Indications
- Lower respiratory tract infections
- Acute Bacterial Otitis Media
- Skin and skin structure infections
- Urinary tract infections
- Gonorrhea
- Bacterial Septicemia
- Bone and joint infections
- Meningitis
- Prevention of postoperative infections
- Perioperative prophylaxis of infections associated with surgery
Pharmacology
- Broad-spectrum parenteral cephalosporin antibiotic
- Bactericidal activity against a wide range of Gram-positive and Gram-negative organisms
- Interferes with the synthesis of the bacterial cell wall
- High degree of stability in the presence of beta lactamases
- Long plasma elimination half-life of about 6 to 9 hours
- Not metabolized in the body
- Excreted unchanged in the urine
- Highly protein bound (95%)
Dosage
- Usual dose for adults: 1 to 2 gm by intravenous or intramuscular administration once a day
- Maximum adult dose: 4 gm/day
- Usual dose for infants and children: 50 to 75 mg/kg intravenous or intramuscular administration once a day
- Maximum pediatric dose: 4 gm/day
- Duration of therapy: 4 to 14 days
Administration
- Preparation of Solutions for Intramuscular / Intravenous Injections
- Administered over 2-4 minutes
- Patient tolerance test recommended before starting treatment
- Freshly reconstituted solution recommended
Interaction
- No drug interactions reported
Contraindications
- History of hypersensitivity to cephalosporin antibiotics
Side Effects
- Gastro-intestinal effects including diarrhea, nausea and vomiting
- Cutaneous reactions including rash, pruritus, urticaria
- Hematologic reactions including eosinophilia, thrombocytopenia, leucopenia
- Hepatic reactions including elevations of SGOT or SGPT, bilirubinemia
- CNS reactions including nervousness, confusion, headache
- Local phlebitis following intravenous administration
Pregnancy & Lactation
- Safety in human pregnancy not established
- Cautious use during lactation
Precautions & Warnings
- Potential for anaphylactic shock
- Incidence of gallbladder sludge
- Regular blood picture checks during prolonged treatment
Use in Special Populations
- Not to be given to neonates if premature or newborn (up to 28 days of age)
Overdose Effects
- No specific antidote
- Treatment should be symptomatic
Therapeutic Class
- Third generation Cephalosporins
Storage Conditions
- Store in a cool, dry place (below 30°C)
- Away from light & moisture
- Keep out of the reach of children