Ceftizone 500 mg/vial (IM Injection)

500 mg vial: ৳ 140.53

Medicine Details

Category Details
Generic Ceftriaxone sodium
Company Renata limited
Also available as
Ceftizone 250 mg injection Ceftizone 1 gm injection Ceftizone 250 mg injection Ceftizone 500 mg injection Ceftizone 1 gm injection Ceftizone 2 gm injection

Indications

  • Lower respiratory tract infections
  • Acute Bacterial Otitis Media
  • Skin and skin structure infections
  • Urinary tract infections
  • Gonorrhea
  • Bacterial Septicemia
  • Bone and joint infections
  • Meningitis
  • Prevention of postoperative infections
  • Perioperative prophylaxis of infections associated with surgery

Pharmacology

Ceftizone is a 3rd generation broad-spectrum parenteral cephalosporin antibiotic. It has potent bactericidal activity against a wide range of Gram-positive and Gram-negative organisms. Like other cephalosporins and penicillins, Ceftizone kills bacteria by interfering with the synthesis of the bacterial cell wall. Ceftizone has a high degree of stability in the presence of beta lactamases. A remarkable feature of Ceftizone is its relatively long plasma elimination half-life of about 6 to 9 hours, which makes single or once-daily dosage of the drug appropriate for most patients. Ceftizone is not metabolized in the body. About 40-65% of a dose of Ceftizone is excreted unchanged in the urine; the remainder is excreted in the bile and ultimately found in the feces as unchanged drug and microbiologically inactive compound. The drug is highly protein bound (95%).

Dosage

  • Adult:
    • 1 to 2 gm by intravenous or intramuscular administration once a day (or in equally divided doses twice a day)
    • Maximum dose: 4 gm/day
  • Infants and Children (01 month or older):
    • 50 to 75 mg/kg intravenous or intramuscular administration once a day (or in equally divided doses twice a day)
    • Maximum dose: 2 gm/day
  • Duration of therapy: Continue for more than 2 days after signs and symptoms of infection have disappeared. Usual duration is 4 to 14 days; in complicated infections, longer therapy may be required.

Administration

  • Preparation of Solutions for Intramuscular / Intravenous Injections
  • For Intramuscular Injection: 250 mg or 500 mg Ceftizone should be dissolved in Lidocaine HCI 1% injection
  • For Intravenous Injection: 250 mg or 500 mg Ceftizone should be dissolved in Water for injection
  • The injection should be administered over 2-4 minutes, by Intramuscular or Intravenous injection or by tubing infusion over a period of 30 minutes at concentration between 10 mg/mL and 40 mg/mL
  • Before starting treatment through Ceftizone injection, patient tolerance test should be checked by administration of a test dose

Interaction

No drug interactions have been reported.

Contraindications

Ceftizone should not be given to patients with a history of hypersensitivity to cephalosporin antibiotics.

Side Effects

  • Gastro-intestinal effects including diarrhea, nausea and vomiting, stomatitis and glossitis
  • Cutaneous reactions including rash, pruritus, urticaria, edema and erythema multiforme
  • Hematologic reactions including eosinophilia, thrombocytopenia, leucopenia, anemia and neutropenia
  • Hepatic reactions including elevations of SGOT or SGPT, bilirubinemia
  • CNS reactions including nervousness, confusion, sleep disturbances, headache, hyperactivity, convulsion, hypertonia and dizziness
  • Local phlebitis occurs rarely following intravenous administration but can be minimized by slow injections over 2-4 minutes

Pregnancy & Lactation

Its safety in human pregnancy has not been established. Therefore, it should not be used in pregnancy unless absolutely indicated. Low concentrations of Ceftizone are excreted in human milk. Caution should be exercised when Ceftizone is administered to a lactating mother.

Precautions & Warnings

  • Anaphylactic shock cannot be ruled out
  • In rare cases, shadows suggesting sludge have been detected by sonograms of the gallbladder
  • During prolonged treatment the blood picture should be checked at regular intervals

Use in Special Populations

Ceftizone must not be given to neonates if the neonates is premature and newborn (up to 28 days of age)

Overdose Effects

There is no specific antidote. Treatment of overdosage should be symptomatic

Therapeutic Class

Third generation Cephalosporins

Storage Conditions

Vial store in a cool, dry place (below 30°C), away from light & moisture. Keep out of the reach of children.

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