Amloten 5 mg+25 mg (Tablet)

Unit Price: ৳ 5.27 (3 x 10: ৳ 158.10)
Strip Price: ৳ 52.70

Medicine Details

Category Details
Generic Amlodipine besilate atenolol
Company Acme laboratories ltd
Also available as
Amloten 5 mg tablet

Indications

  • Patients with essential hypertension
  • Patients with angina pectoris & hypertension as co-existing diseases
  • In post Ml patients
  • In patients with refractory angina pectoris where nitrate therapy has failed.

Pharmacology

  • Fixed-dose combination of Amlodipine and Atenolol
  • Amlodipine is a dihydropyridine calcium antagonist
  • Amlodipine acts directly on vascular smooth muscle
  • Atenolol is a cardioselective beta-blocker
  • Atenolol causes a reduction in blood pressure by lowering cardiac output
  • Atenolol decreases the plasma renin activity and sympathetic outflow from CNS

Dosage & Administration

  • Recommended dosage: Amlodipine and Atenolol 5/25 mg tablet once daily
  • Dosage may be increased to 5/25 mg two tablets daily or as advised by physicians
  • Dosage should be individualized

Interaction

  • Disopyramide: Atenolol reduces the clearance of disopyramide by 20%
  • Ampicillin at doses of 1 gm and above may reduce Atenolol levels
  • Oral antidiabetics and insulin: Beta-blockers may decrease tissue sensitivity to insulin and inhibit insulin secretion

Contraindications

  • Hypersensitivity to either component
  • Sinus bradycardia
  • Second and higher degrees of heart block
  • Cardiogenic shock
  • Hypotension
  • Congestive heart failure
  • Poor left ventricular function

Side Effects

  • Fatigue
  • Headache
  • Edema
  • Nausea
  • Drowsiness
  • Anxiety
  • Depression

Pregnancy & Lactation

  • Should be used during pregnancy only if the expected benefit outweighs the potential fetal risk
  • Should not be used by nursing mothers

Precautions & Warnings

  • Bronchospasm: Use with caution in patients with airway obstruction
  • Renal impairment: Use with caution in patients with renal impairment
  • Hepatic impairment: Caution may be necessary in the use of the combination in patients with severe liver damage
  • Drug withdrawal: patients should be warned against stopping the drug suddenly

Overdose Effects

  • Hypotension
  • Congestive cardiac failure
  • Unabsorbed drugs may be removed by gastric lavage
  • Symptomatic treatment is suggested

Therapeutic Class

  • Combined antihypertensive preparations

Storage Conditions

  • Keep below 30°C temperature
  • Away from light & moisture
  • Keep out of the reach of children

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