Amloten 5 mg+25 mg (Tablet)
Unit Price: ৳ 5.27 (3 x 10: ৳ 158.10)
Strip Price: ৳ 52.70
Medicine Details
Category | Details |
---|---|
Generic | Amlodipine besilate atenolol |
Company | Acme laboratories ltd |
Also available as |
Indications
- Patients with essential hypertension
- Patients with angina pectoris & hypertension as co-existing diseases
- In post Ml patients
- In patients with refractory angina pectoris where nitrate therapy has failed.
Pharmacology
- Fixed-dose combination of Amlodipine and Atenolol
- Amlodipine is a dihydropyridine calcium antagonist
- Amlodipine acts directly on vascular smooth muscle
- Atenolol is a cardioselective beta-blocker
- Atenolol causes a reduction in blood pressure by lowering cardiac output
- Atenolol decreases the plasma renin activity and sympathetic outflow from CNS
Dosage & Administration
- Recommended dosage: Amlodipine and Atenolol 5/25 mg tablet once daily
- Dosage may be increased to 5/25 mg two tablets daily or as advised by physicians
- Dosage should be individualized
Interaction
- Disopyramide: Atenolol reduces the clearance of disopyramide by 20%
- Ampicillin at doses of 1 gm and above may reduce Atenolol levels
- Oral antidiabetics and insulin: Beta-blockers may decrease tissue sensitivity to insulin and inhibit insulin secretion
Contraindications
- Hypersensitivity to either component
- Sinus bradycardia
- Second and higher degrees of heart block
- Cardiogenic shock
- Hypotension
- Congestive heart failure
- Poor left ventricular function
Side Effects
- Fatigue
- Headache
- Edema
- Nausea
- Drowsiness
- Anxiety
- Depression
Pregnancy & Lactation
- Should be used during pregnancy only if the expected benefit outweighs the potential fetal risk
- Should not be used by nursing mothers
Precautions & Warnings
- Bronchospasm: Use with caution in patients with airway obstruction
- Renal impairment: Use with caution in patients with renal impairment
- Hepatic impairment: Caution may be necessary in the use of the combination in patients with severe liver damage
- Drug withdrawal: patients should be warned against stopping the drug suddenly
Overdose Effects
- Hypotension
- Congestive cardiac failure
- Unabsorbed drugs may be removed by gastric lavage
- Symptomatic treatment is suggested
Therapeutic Class
- Combined antihypertensive preparations
Storage Conditions
- Keep below 30°C temperature
- Away from light & moisture
- Keep out of the reach of children