Ceftrix 500 mg/vial (IM Injection)
500 mg vial: ৳ 130.39
Medicine Details
| Category | Details |
|---|---|
| Generic | Ceftriaxone sodium |
| Company | Novo healthcare and pharma ltd |
| Also available as |
Indications
- Lower respiratory tract infections
- Acute Bacterial Otitis Media
- Skin and skin structure infections
- Urinary tract infections
- Gonorrhea
- Bacterial Septicemia
- Bone and joint infections
- Meningitis
- Prevention of postoperative infections
- Perioperative prophylaxis of infections associated with surgery
Pharmacology
- Broad-spectrum parenteral cephalosporin antibiotic
- Bactericidal activity against Gram-positive and Gram-negative organisms
- Interferes with the synthesis of the bacterial cell wall
- Stable in the presence of beta lactamases
- Relatively long plasma elimination half-life of 6 to 9 hours
- Not metabolized in the body
- Highly protein bound (95%)
Dosage
- Usual adult dose of 1 to 2 gm by intravenous or intramuscular administration once a day
- Different doses for specific infections such as pneumonia, bronchitis, otitis media, skin infections, urinary tract infections, septicemia, bone and joint infections, meningitis, and surgical prophylaxis
- Usual infant and child dose of 50 to 75 mg/kg intravenous or intramuscular administration once a day
Administration
- Preparation of solutions for intramuscular and intravenous injections
- Injection administered over specified time periods
- Recommendation for patient tolerance test before treatment
Interaction
- No reported drug interactions
Contraindications
- Patients with history of hypersensitivity to cephalosporin antibiotics
Side Effects
- Gastrointestinal effects including diarrhea, nausea, vomiting, stomatitis, and glossitis
- Cutaneous reactions including rash, pruritus, urticaria, edema, and erythema multiforme
- Hematologic reactions including eosinophilia, thrombocytopenia, leucopenia, anemia, and neutropenia
- Hepatic reactions including elevations of SGOT or SGPT, bilirubinemia
- CNS reactions including nervousness, confusion, sleep disturbances, headache, hyperactivity, convulsion, hypertonia, and dizziness
- Rare occurrence of local phlebitis following intravenous administration
Pregnancy & Lactation
- Safety in human pregnancy not established
- Caution advised when administered to lactating mothers
Precautions & Warnings
- Possibility of anaphylactic shock
- Rare findings suggesting sludge in the gallbladder
- Recommended blood picture checks during prolonged treatment
Use in Special Populations
- Avoid use in premature and newborn neonates up to 28 days of age
Overdose Effects
- No specific antidote
- Symptomatic treatment advised
Therapeutic Class
- Third generation Cephalosporins
Storage Conditions
- Vial storage in a cool, dry place below 30°C
- Keep away from light and moisture
- Keep out of the reach of children