Ceftrix 1 gm/vial (IV Injection)

1 gm vial: ৳ 160.48

Medicine Details

Category	Details
Generic	Ceftriaxone sodium
Company	Novo healthcare and pharma ltd
Also available as	Ceftrix 250 mg injection Ceftrix 500 mg injection Ceftrix 2 gm injection

Indications

Lower respiratory tract infections
Acute Bacterial Otitis Media
Skin and skin structure infections
Urinary tract infections
Gonorrhea
Bacterial Septicemia
Bone and joint infections
Meningitis
Prevention of postoperative infections
Perioperative prophylaxis of infections associated with surgery

Pharmacology

Ceftriaxone is a 3rd generation broad-spectrum parenteral cephalosporin antibiotic with potent bactericidal activity against a wide range of Gram-positive and Gram-negative organisms. It kills bacteria by interfering with the synthesis of the bacterial cell wall and has a long plasma elimination half-life of about 6 to 9 hours. It is not metabolized in the body and is highly protein bound (95%).

Dosage

Usual dose for adults is 1 to 2 gm by intravenous or intramuscular administration once a day or in equally divided doses twice a day. Maximum dose is 4 gm/day.
Usual dose for infants and children (01 month or older) is 50 to 75 mg/kg intravenous or intramuscular administration once a day or in equally divided doses twice a day. Maximum dose varies based on the infection type.

Administration

Preparation of solutions for intramuscular or intravenous injections is recommended. Injection should be administered over 2-4 minutes and patient tolerance test is necessary before starting treatment through Ceftriaxone injection.

Interaction

No drug interactions reported.

Contraindications

Not to be given to patients with a history of hypersensitivity to cephalosporin antibiotics.

Side Effects

Common: gastro-intestinal effects, cutaneous reactions, hematologic reactions, hepatic reactions, CNS reactions
Rare: local phlebitis following intravenous administration

Pregnancy & Lactation

Safety in human pregnancy not established. Caution advised during lactation.

Precautions & Warnings

Potential for anaphylactic shock
Rare cases of gallbladder abnormalities detected by sonograms

Use in Special Populations

Avoid in neonates if premature or newborn (up to 28 days of age).

Overdose Effects

No specific antidote. Treatment of overdosage should be symptomatic.

Therapeutic Class

Third generation Cephalosporins

Storage Conditions

Vial should be stored in a cool, dry place (below 30° C), away from light & moisture.