Ceftron 500 mg/vial (IM Injection)

500 mg vial: ৳ 200.00

Medicine Details

Category Details
Generic Ceftriaxone sodium
Company Square pharmaceuticals plc
Also available as
Ceftron 250 mg injection Ceftron 1 gm injection Ceftron 250 mg injection Ceftron 500 mg injection Ceftron 1 gm injection Ceftron 2 gm injection

Indications

  • Lower respiratory tract infections
  • Acute Bacterial Otitis Media
  • Skin and skin structure infections
  • Urinary tract infections
  • Gonorrhea
  • Bacterial Septicemia
  • Bone and joint infections
  • Meningitis
  • Prevention of postoperative infections
  • Perioperative prophylaxis of infections associated with surgery

Pharmacology

  • 3rd generation broad-spectrum parenteral cephalosporin antibiotic
  • Bactericidal activity against a wide range of Gram-positive and Gram-negative organisms
  • Interferes with the synthesis of the bacterial cell wall
  • High degree of stability in the presence of beta lactamases
  • Long plasma elimination half-life of about 6 to 9 hours
  • Not metabolized in the body
  • Excretion of 40-65% unchanged in the urine
  • Highly protein bound (95%)

Dosage

  • Usual dose for adults is 1 to 2 gm by intravenous or intramuscular administration once a day
  • Maximum dose for adults is 4 gm/day
  • Usual dose for infants and children (01 month or older) is 50 to 75 mg/kg intravenous or intramuscular administration once a day
  • Maximum dose for infants and children is 2 gm/day
  • Uncomplicated gonococcal infections: 250 mg IM as a single dose
  • Surgical prophylaxis: 1 g IV as a single dose 30 to 120 minutes before surgery
  • Duration of therapy: Usually 4 to 14 days

Administration

  • Preparation of Solutions for Intramuscular / Intravenous Injections
  • Different dissolution requirements for intramuscular and intravenous injections
  • Injection should be administered over specific time periods and concentrations
  • Patient tolerance test recommended before starting treatment

Interaction

  • No reported drug interactions

Contraindications

  • Not to be given to patients with a history of hypersensitivity to cephalosporin antibiotics

Side Effects

  • Gastro-intestinal effects including diarrhea, nausea, and vomiting
  • Cutaneous reactions including rash, pruritus, urticaria, edema, and erythema multiforme
  • Hematologic reactions including eosinophilia, thrombocytopenia, leucopenia, anemia, and neutropenia
  • Hepatic reactions including elevations of SGOT or SGPT, bilirubinemia
  • CNS reactions including nervousness, confusion, sleep disturbances, headache, convulsion, hypertonia, and dizziness
  • Rare occurrence of local phlebitis following intravenous administration

Pregnancy & Lactation

  • Safety in human pregnancy not established
  • Caution advised when administered to lactating mothers

Precautions & Warnings

  • Potential for anaphylactic shock
  • Rare cases of gallbladder sludge detected
  • Blood picture should be checked at regular intervals during prolonged treatment

Use in Special Populations

  • Not to be given to neonates if premature and newborn (up to 28 days of age)

Overdose Effects

  • No specific antidote
  • Treatment should be symptomatic

Therapeutic Class

  • Third generation Cephalosporins

Storage Conditions

  • Vial store in a cool, dry place (below 30°C)
  • Store away from light & moisture
  • Keep out of the reach of children

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