Ceftron 1 gm/vial (IV Injection)
1 gm vial: ৳ 280.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Ceftriaxone sodium |
| Company | Square pharmaceuticals plc |
| Also available as |
Indications
- Lower respiratory tract infections
- Acute Bacterial Otitis Media
- Skin and skin structure infections
- Urinary tract infections
- Gonorrhea
- Bacterial Septicemia
- Bone and joint infections
- Meningitis
- Prevention of postoperative infections
- Perioperative prophylaxis of infections associated with surgery
Pharmacology
- Broad-spectrum parenteral cephalosporin antibiotic
- Potent bactericidal activity against a wide range of organisms
- Kills bacteria by interfering with synthesis of the bacterial cell wall
- High degree of stability in the presence of beta lactamases
- Relatively long plasma elimination half-life of about 6 to 9 hours
- Not metabolized in the body
- About 40-65% of dose excreted unchanged in the urine
- Highly protein bound (95%)
Dosage
- Usual adult dose: 1 to 2 gm intravenous or intramuscular administration once a day
- Maximum adult dose: 4 gm/day
- Usual pediatric dose: 50 to 75 mg/kg intravenous or intramuscular administration once a day
- Maximum pediatric dose: 2 gm/day
- Duration of therapy: 4 to 14 days
Administration
- Preparation of solutions for intramuscular/intravenous injections
- Dissolution in Lidocaine HCI 1% or Water for injection USP
- Recommended injection administration over 2-4 minutes
- Patient tolerance test recommended before treatment
- Freshly reconstituted solution recommended
Interaction
- No reported drug interactions
Contraindications
- Patients with a history of hypersensitivity to cephalosporin antibiotics
Side Effects
- Gastro-intestinal effects including diarrhea, nausea, vomiting, stomatitis, and glossitis
- Cutaneous reactions including rash, pruritus, urticaria, edema, and erythema multiforme
- Hematologic reactions including eosinophilia, thrombocytopenia, leucopenia, anemia, and neutropenia
- Hepatic reactions including elevations of SGOT or SGPT, and bilirubinemia
- CNS reactions including nervousness, confusion, sleep disturbances, headache, and dizziness
- Local phlebitis occurs rarely following intravenous administration
Pregnancy & Lactation
- Safety in human pregnancy not established
- Caution in lactating mothers
Precautions & Warnings
- Anaphylactic shock cannot be ruled out
- Shadows suggesting sludge detected by sonograms of the gallbladder in rare cases
- Blood picture should be checked at regular intervals during prolonged treatment
Use in Special Populations
- Not to be given to premature and newborn neonates (up to 28 days of age)
Overdose Effects
- No specific antidote
- Symptomatic treatment recommended
Therapeutic Class
- Third generation Cephalosporins
Storage Conditions
- Store in a cool, dry place (below 30°C)
- Keep away from light and moisture
- Keep out of the reach of children