Dicephin 250 mg/vial (IM Injection)
250 mg vial: ৳ 100.30
Medicine Details
| Category | Details |
|---|---|
| Generic | Ceftriaxone sodium |
| Company | Drug international ltd |
| Also available as |
Title
- Dicephin
Categories
- Antibiotic
- Pharmaceutical
Description
- Ceftriaxone is a 3rd generation broad-spectrum parenteral cephalosporin antibiotic
- Potent bactericidal activity against a wide range of Gram-positive and Gram-negative organisms
- Kills bacteria by interfering with the synthesis of the bacterial cell wall
- High stability in the presence of beta lactamases
- Relatively long plasma elimination half-life of about 6 to 9 hours
- Not metabolized in the body
- 40-65% of a dose of Ceftriaxone is excreted unchanged in the urine
- Highly protein bound (95%)
- Usual dosage for adults: 1 to 2 gm by intravenous or intramuscular administration once a day or twice a day
- Maximum adult dose: 4 gm/day
- Usual dosage for infants and children: 50 to 75 mg/kg intravenous or intramuscular administration once a day or twice a day
- Maximum pediatric dose: 4 gm/day
- Usual duration of therapy: 4 to 14 days
- Intramuscular injection preparation: 250 mg or 500 mg Ceftriaxone should be dissolved in 2 ml Lidocaine HCI 1% injection or 1 g Ceftriaxone in 3.5 ml of Lidocaine HCI 1% injection
- Intravenous injection preparation: 250 mg or 500 mg Ceftriaxone should be dissolved in 5 ml of Water for injection or 1 g Ceftriaxone in 10 ml of Water for injection USP or 2 g Ceftriaxone in 20 ml of Water for injection
- Injection should be administered over 2-4 minutes or by tubing infusion over a period of 30 minutes at specific concentrations
- No reported drug interactions
- Contraindicated in patients with a history of hypersensitivity to cephalosporin antibiotics
- Side effects may include gastrointestinal effects, cutaneous reactions, hematologic reactions, hepatic reactions, CNS reactions, and rare occurrence of local phlebitis following intravenous administration
- Safety in human pregnancy has not been established
- Low concentrations of Ceftriaxone are excreted in human milk
- Anaphylactic shock cannot be ruled out, requires immediate countermeasures
- Shadows suggesting sludge have been detected by sonograms of the gallbladder in rare cases
- Must not be given to neonates if premature and newborn (up to 28 days of age)
- No specific antidote for overdose, treatment should be symptomatic
- Therapeutic class: Third generation Cephalosporins
- Vial should be stored in a cool, dry place (below 30° C), away from light and moisture, out of the reach of children