Dicephin 250 mg/vial (IM Injection)

250 mg vial: ৳ 100.30

Medicine Details

Category Details
Generic Ceftriaxone sodium
Company Drug international ltd
Also available as
Dicephin 500 mg injection Dicephin 1 gm injection Dicephin 250 mg injection Dicephin 500 mg injection Dicephin 1 gm injection Dicephin 2 gm injection

Title

  • Dicephin

Categories

  • Antibiotic
  • Pharmaceutical

Description

  • Ceftriaxone is a 3rd generation broad-spectrum parenteral cephalosporin antibiotic
  • Potent bactericidal activity against a wide range of Gram-positive and Gram-negative organisms
  • Kills bacteria by interfering with the synthesis of the bacterial cell wall
  • High stability in the presence of beta lactamases
  • Relatively long plasma elimination half-life of about 6 to 9 hours
  • Not metabolized in the body
  • 40-65% of a dose of Ceftriaxone is excreted unchanged in the urine
  • Highly protein bound (95%)
  • Usual dosage for adults: 1 to 2 gm by intravenous or intramuscular administration once a day or twice a day
  • Maximum adult dose: 4 gm/day
  • Usual dosage for infants and children: 50 to 75 mg/kg intravenous or intramuscular administration once a day or twice a day
  • Maximum pediatric dose: 4 gm/day
  • Usual duration of therapy: 4 to 14 days
  • Intramuscular injection preparation: 250 mg or 500 mg Ceftriaxone should be dissolved in 2 ml Lidocaine HCI 1% injection or 1 g Ceftriaxone in 3.5 ml of Lidocaine HCI 1% injection
  • Intravenous injection preparation: 250 mg or 500 mg Ceftriaxone should be dissolved in 5 ml of Water for injection or 1 g Ceftriaxone in 10 ml of Water for injection USP or 2 g Ceftriaxone in 20 ml of Water for injection
  • Injection should be administered over 2-4 minutes or by tubing infusion over a period of 30 minutes at specific concentrations
  • No reported drug interactions
  • Contraindicated in patients with a history of hypersensitivity to cephalosporin antibiotics
  • Side effects may include gastrointestinal effects, cutaneous reactions, hematologic reactions, hepatic reactions, CNS reactions, and rare occurrence of local phlebitis following intravenous administration
  • Safety in human pregnancy has not been established
  • Low concentrations of Ceftriaxone are excreted in human milk
  • Anaphylactic shock cannot be ruled out, requires immediate countermeasures
  • Shadows suggesting sludge have been detected by sonograms of the gallbladder in rare cases
  • Must not be given to neonates if premature and newborn (up to 28 days of age)
  • No specific antidote for overdose, treatment should be symptomatic
  • Therapeutic class: Third generation Cephalosporins
  • Vial should be stored in a cool, dry place (below 30° C), away from light and moisture, out of the reach of children

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