Dicephin 1 gm/vial (IM Injection)

1 gm vial: ৳ 190.60

Medicine Details

Category Details
Generic Ceftriaxone sodium
Company Drug international ltd
Also available as
Dicephin 250 mg injection Dicephin 500 mg injection Dicephin 250 mg injection Dicephin 500 mg injection Dicephin 1 gm injection Dicephin 2 gm injection

Title

  • Dicephin (Ceftriaxone)

Categories

  • Antibiotics
  • Medication
  • Pharmaceuticals

Indications

  • Lower respiratory tract infections
  • Acute Bacterial Otitis Media
  • Skin and skin structure infections
  • Urinary tract infections
  • Gonorrhea
  • Bacterial Septicemia
  • Bone and joint infections
  • Meningitis
  • Prevention of postoperative infections
  • Perioperative prophylaxis of infections associated with surgery

Pharmacology

Ceftriaxone is a 3rd generation broad-spectrum parenteral cephalosporin antibiotic with potent bactericidal activity against a wide range of Gram-positive and Gram-negative organisms. It interferes with the synthesis of the bacterial cell wall and has a relatively long plasma elimination half-life of about 6 to 9 hours. It is not metabolized in the body and is excreted unchanged in the urine.

Dosage

  • Adult: 1 to 2 gm by intravenous or intramuscular administration once a day (or in equally divided doses twice a day)
  • Infants and Children (01 month or older): 50 to 75 mg/kg intravenous or intramuscular administration once a day (or in equally divided doses twice a day)

Administration

  • Intramuscular Injection:
    • 250 mg or 500 mg Ceftriaxone should be dissolved in Lidocaine HCI 1% injection
    • 1 g Ceftriaxone in 3.5 ml of Lidocaine HCI 1% injection
  • Intravenous Injection:
    • 250 mg or 500 mg Ceftriaxone should be dissolved in Water for injection
    • 1 g Ceftriaxone in 10 ml of Water for injection USP
    • 2 g Ceftriaxone in 20 ml of Water for injection

Interaction

No drug interactions have been reported.

Contraindications

  • History of hypersensitivity to cephalosporin antibiotics

Side Effects

  • Gastro-intestinal effects:
    • Diarrhea
    • Nausea
    • Vomiting
    • Stomatitis
    • Glossitis
  • Cutaneous reactions:
    • Rash
    • Pruritus
    • Urticaria
    • Edema
    • Erythema multiforme
  • Hematologic reactions:
    • Eosinophilia
    • Thrombocytopenia
    • Leucopenia
    • Anemia
    • Neutropenia
  • Hepatic reactions:
    • Elevations of SGOT or SGPT
    • Bilirubinemia
  • CNS reactions:
    • Nervousness
    • Confusion
    • Sleep disturbances
    • Headache
  • Local reactions:
    • Phlebitis following intravenous administration

Pregnancy & Lactation

  • Not established for safety in human pregnancy, caution in lactating mothers

Precautions & Warnings

  • Risk of anaphylactic shock
  • Monitoring of blood picture during prolonged treatment

Use in Special Populations

  • Contraindicated in premature and newborn neonates (up to 28 days of age)

Overdose Effects

  • No specific antidote, treatment should be symptomatic

Therapeutic Class

  • Third generation Cephalosporins

Storage Conditions

  • Store in a cool, dry place below 30°C, away from light and moisture, keep out of the reach of children

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