Dicephin 2 gm/vial (IV Injection)
2 gm vial: ৳ 301.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Ceftriaxone sodium |
| Company | Drug international ltd |
| Also available as |
Title
- Dicephin
Categories
- Medicine
- Antibiotic
- Pharmaceutical
Description
- Dicephin is a Ceftriaxone-based antibiotic indicated for the treatment of various major infections such as lower respiratory tract infections, acute bacterial otitis media, skin and skin structure infections, urinary tract infections, gonorrhea, bacterial septicemia, bone and joint infections, meningitis, and prevention of postoperative infections.
Indications
- Lower respiratory tract infections
- Acute Bacterial Otitis Media
- Skin and skin structure infections
- Urinary tract infections
- Gonorrhea
- Bacterial Septicemia
- Bone and joint infections
- Meningitis
- Prevention of postoperative infections
- Perioperative prophylaxis of infections associated with surgery
Pharmacology
- Broad-spectrum parenteral cephalosporin antibiotic
- Potent bactericidal activity against Gram-positive and Gram-negative organisms
- Interferes with bacterial cell wall synthesis
- High degree of stability in the presence of beta lactamases
- Long plasma elimination half-life of 6 to 9 hours
- Not metabolized in the body
- Highly protein bound (95%)
Dosage
- Usual dose for adults is 1 to 2 gm by intravenous or intramuscular administration once a day
- Usual dose for infants and children is 50 to 75 mg/kg intravenous or intramuscular administration once a day
- Duration of therapy: Usually 4 to 14 days
Administration
- Preparation of Solutions for Intramuscular / Intravenous Injections
- Test dose recommended before starting treatment through Ceftriaxone injection
- Administration over 2-4 minutes for intramuscular or intravenous injection or by tubing infusion over a period of 30 minutes
- Freshly reconstituted solution recommended
- Maintains potency for at least 6 hours at room temperature or 24 hours at 5°C
Interaction
- No drug interactions reported
Contraindications
- Hypersensitivity to cephalosporin antibiotics
Side Effects
- Gastro-intestinal effects including diarrhea, nausea, vomiting, stomatitis, and glossitis
- Cutaneous reactions including rash, pruritus, urticaria, edema, and erythema multiforme
- Hematologic reactions including eosinophilia, thrombocytopenia, leucopenia, anemia, and neutropenia
- Hepatic reactions including elevations of SGOT or SGPT, bilirubinemia
- CNS reactions including nervousness, confusion, sleep disturbances, headache, hyperactivity, convulsion, hypertonia, and dizziness
- Local phlebitis occurs rarely following intravenous administration
- Minimize local phlebitis by slow injections
Pregnancy & Lactation
- Safety in human pregnancy not established
- Caution advised during lactation
Precautions & Warnings
- Anaphylactic shock possible, require immediate countermeasures
- Shadows suggesting sludge in the gallbladder detected in rare cases
- Blood picture should be checked at regular intervals during prolonged treatment
Use in Special Populations
- Avoid in neonates if premature and newborn (up to 28 days of age)
Overdose Effects
- No specific antidote
- Treatment should be symptomatic
Therapeutic Class
- Third generation Cephalosporins
Storage Conditions
- Store in a cool, dry place below 30°C
- Keep away from light and moisture
- Keep out of the reach of children