Eracef 1 gm/vial (IM Injection)

1 gm vial: ৳ 190.00

Medicine Details

Category Details
Generic Ceftriaxone sodium
Company Popular pharmaceuticals ltd
Also available as
Eracef 250 mg injection Eracef 500 mg injection Eracef 500 mg injection Eracef 1 gm injection Eracef 2 gm injection

Indications

  • Lower respiratory tract infections
  • Acute Bacterial Otitis Media
  • Skin and skin structure infections
  • Urinary tract infections
  • Gonorrhea
  • Bacterial Septicemia
  • Bone and joint infections
  • Meningitis
  • Prevention of postoperative infections
  • Perioperative prophylaxis of infections associated with surgery

Pharmacology

Ceftriaxone is a 3rd generation broad-spectrum parenteral cephalosporin antibiotic with potent bactericidal activity against a wide range of Gram-positive and Gram-negative organisms. It interferes with the synthesis of the bacterial cell wall and has a relatively long plasma elimination half-life of about 6 to 9 hours. It is not metabolized in the body and is highly protein bound (95%).

Dosage

  • Adult: 1 to 2 gm by intravenous or intramuscular administration once a day (or in equally divided doses twice a day)
  • Infants and Children (01 month or older): 50 to 75 mg/kg intravenous or intramuscular administration once a day (or in equally divided doses twice a day)
  • Duration of therapy: Continue for more than 2 days after signs and symptoms of infection have disappeared. Usual duration is 4 to 14 days; in complicated infections, longer therapy may be required.

Administration

  • Intramuscular Injection: 250 mg or 500 mg Ceftriaxone should be dissolved in Lidocaine HCI 1% injection
  • Intravenous Injection: 250 mg or 500 mg Ceftriaxone should be dissolved in Water for injection or 1 g Ceftriaxone in 10 ml of Water for injection USP or 2 g Ceftriaxone in 20 ml of Water for injection
  • Administered over 2-4 minutes for both Intramuscular and Intravenous injection or by tubing infusion over a period of 30 minutes at concentration between 10 mg/mL and 40 mg/mL
  • Patient tolerance test should be checked before starting treatment through Ceftriaxone injection

Interaction

No drug interactions reported

Contraindications

Patients with a history of hypersensitivity to cephalosporin antibiotics

Side Effects

  • Gastro-intestinal effects including diarrhea, nausea and vomiting, stomatitis and glossitis
  • Cutaneous reactions including rash, pruritus, urticaria, edema and erythema multiforme
  • Hematologic reactions including eosinophilia, thrombocytopenia, leucopenia, anemia and neutropenia
  • Hepatic reactions including elevations of SGOT or SGPT, bilirubinemia
  • CNS reactions including nervousness, confusion, sleep disturbances, headache, hyperactivity, convulsion, hypertonia and dizziness
  • Local phlebitis occurs rarely following intravenous administration

Pregnancy & Lactation

Safety in human pregnancy has not been established. Low concentrations of Ceftriaxone are excreted in human milk. Caution should be exercised when administered to lactating mothers.

Precautions & Warnings

  • Anaphylactic shock cannot be ruled out
  • Shadows suggesting sludge have been detected by sonograms of the gallbladder in rare cases
  • Blood picture should be checked at regular intervals during prolonged treatment

Use in Special Populations

Must not be given to neonates if premature and newborn (up to 28 days of age)

Overdose Effects

No specific antidote. Treatment should be symptomatic

Therapeutic Class

Third generation Cephalosporins

Storage Conditions

Vial store in a cool, dry place (below 30°C), away from light & moisture. Keep out of the reach of children

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